张波,耿彬,谭小义,姜金,陈聪,Chandan Kumar Jayswal,吴卓,夏亚一

• 1:兰州大学第二临床医学院骨科

摘要(Abstract)：

该综述介绍了MAPK信号通路(ERK1/2、JNK、P38和ERK5)与骨质疏松相关因子的关系,明确了MAPK信号通路参与骨质疏松的发生与发展。通过药物干预RANKL、OPG、1,25(OH)2D3、PTH、BMP、TGF-β、IL-1、IL-6、TNF-α和雌激素等因子而作用于MAPK信号通路,可提高骨质疏松的治疗效果。但IL6和TNF-α调节MAPK信号通路参与骨质疏松发生发展的作用还不清楚。骨质疏松发病机制复杂,多种相关信号通路之间存在交互和交叉的作用,以及ERK5通路在骨质疏松中发挥的作用还有待进一步研究。

关键词(KeyWords)： 信号传导通路;MAPK;骨质疏松

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(编号:81071478);; 甘肃省自然基金(1107RJZA144)

作者(Author): 张波,耿彬,谭小义,姜金,陈聪,Chandan Kumar Jayswal,吴卓,夏亚一

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