冯萌;邱裕生;陈迁;张龙;刘文光;彭航;张智;

• 1:西安交通大学第一附属医院骨科
• 2:西安交通大学第一附属医院骨骼关节疾病与治疗研究中心

摘要(Abstract)：

[目的]综述骨关节炎骨软骨损伤修复的难点及研究进展。[方法]通过检索Pub Med数据库,分析总结近5年骨软骨再生及修复的相关文献。[结果]由于软骨下骨硬化、骨软骨界面的完整性破坏以及新生血管形成,骨关节炎的关节软骨损伤加重,同时滑膜炎时炎症因子分泌增加,抗炎的生物治疗及抑制新生血管形成对于骨软骨修复颇有前景。另一方面,随着表观遗传学的发展及软骨细胞能量代谢(缺氧诱导因子-1α)与全身代谢尤其是过氧化物酶体增殖物激活受体的研究促进了骨软骨损伤的机制研究。利用脂肪干细胞及内源性细胞归巢为骨软骨损伤修复提供了新思路,但仍面临着软骨细胞老化的难题。[结论]骨软骨再生目前比较成熟,而在体内试验时,骨软骨微环境难以维持并且软骨老化,不能长时间维持软骨生物学功能是目前骨软骨修复最大的挑战。

关键词(KeyWords)： 骨软骨损伤修复;骨软骨界面;血管形成;细胞归巢

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(编号:81371943;81501892)

作者(Author): 冯萌;邱裕生;陈迁;张龙;刘文光;彭航;张智;

Email:

DOI:

参考文献(References)：

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