刘振东;秦泗河;

• 1:解放军第230医院骨科
• 2:北京市国家康复辅具中心附属康复医院

摘要(Abstract)：

所有的骨再生都起源于干细胞。骨痂的形成是由刺激信号引发的细胞再生过程。多种多样的骨修复现象可能具有相同的细胞学链条机制。血管内皮细胞在骨再生的启动阶段发挥重要作用,但不具备特异性。破骨细胞通过分泌BMP触发了干细胞向骨细胞的特异性分化。骨折愈合的漫长过程是骨痂形成反应不断重复和叠加的结果。由超负荷诱发的应力-血管生成-骨再生的偶联效应是骨痂形成的基本病理基础。骨再生具有放大的骨生成效应,不同的固定方式可以影响骨再生的效率,适当的超负荷可以导致放大的骨再生,应力遮挡妨碍骨痂的形成,而不稳定的固定可以导致磨损性骨吸收。可以根据骨痂的形态学表现来推断骨折间隙力学环境的合理性,进而采取适当的措施进行骨痂调控。

关键词(KeyWords)： 骨痂;骨折愈合;骨再生;干细胞

Abstract:

Keywords:

基金项目(Foundation): 全军医药卫生“十五”青年基金资助课题(编号:01Q007)

作者(Author): 刘振东;秦泗河;

Email:

DOI:

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