骨关节炎软骨中Ⅰ型和Ⅱ型胶原的分布Immunohistochemical Distribution of Type Ⅰ and Ⅱ Collagen in Osteoarthritis
姚力,周乙雄,赵丹惠,黄靖香,薛延
摘要(Abstract)：
目的 :研究骨关节炎软骨中Ⅰ型和Ⅱ型胶原的分布。方法 :从正常关节软骨和骨关节炎软骨上取样本做切片。所有样本行HE、蕃红 0染色及Ⅰ型和Ⅱ型胶原免疫组化。结果 :骨关节炎软骨中Ⅱ型胶原免疫组化染色不均匀。Ⅰ型胶原染色 ,在表层和中层的部分区域有不规则着色。纤维样组织中 ,Ⅰ型胶原免疫组化呈阳性 ,Ⅱ型胶原免疫组化不着色。结论 :骨关节软骨基质中Ⅱ型胶原和蛋白聚糖的破坏增强与软骨细胞对其合成增强同时存在 ,软骨修复的过程中 ,部分软骨细胞发生去分化 ,而表达Ⅰ型胶原
关键词(KeyWords)： Ⅰ型胶原;Ⅱ型胶原;骨关节炎;免疫组化
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作者(Author): 姚力,周乙雄,赵丹惠,黄靖香,薛延
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