碱性成纤维细胞生长因子复合部分脱蛋白骨修复兔股骨头骨缺损的作用机理及相关性分析Correlation analysis and mechanism study on the repair of femoral head defects with bFGF/PDPB
李晓辉,宋跃明,龚跃昆,李世和,赵学凌,李彦林,李亚利
摘要(Abstract)：
目的:探讨bFGF/PDPB在修复兔股骨头骨缺损过程中成骨与再血管化作用的相关性及其作用机理。方法:成年健康新西兰白兔24只48髋随机分为3组,每组16髋,建立股骨头骨缺损模型,A组植入bFGF/PDPB、B组植入PDPB、C组为空白对照。动物于术后2、4、8周分批处死,并制备墨汁灌注标本,进行组织学和微血管观察及血管密度图像分析,计数成骨细胞数和破骨细胞数,测定骨钙含量,并进行相关性分析。结果:A组骨缺损修复早于B和C组,C组术后8周缺损区仍存在;A组术后8周骨钙含量和血管密度高于B和C组;术后各时点血管密度与成骨细胞数成正相关;与破骨细胞于术后2周成正相关;与骨钙含量于术后2周呈负相关,术后8周呈正相关。结论:bFGF具有成骨和再血管化作用,促进移植材料的爬行替代,在治疗股骨头坏死方面具备一定的潜能和优势。
关键词(KeyWords)： 股骨头坏死;成纤维细胞生长因子;部分脱蛋白骨
基金项目(Foundation): 云南省教育厅科学研究基金项目(NO.02ZY251)
作者(Author): 李晓辉,宋跃明,龚跃昆,李世和,赵学凌,李彦林,李亚利
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DOI:
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