徐闯;刘明廷;孟涛;石辉;王建明;李健;杜长岭;

• 1:滨州医学院附属医院骨关节外科

摘要(Abstract)：

[目的]用Meta分析的方法探讨局部与静脉应用氨甲环酸(tranexamic acid,TXA)对全髋关节置换术(total hip arthroplasty,THA)的安全性及有效性。[方法]计算机检索Pub Med、EBSCO、The Cochrane Library数据库、中国知网、万方数据库,检索内容为关于局部应用TXA减少THA出血量的临床随机对照试验(randomized controlled trial,RCT)和半随机对照试验(q RCT),检索时限为1999年1月~2016年6月。按纳入、排除标准进行文献筛选和质量评估,应用Rev Man 5.2软件进行Meta分析。[结果]纳入8篇文献,2 144例患者,局部应用氨甲环酸组789例,静脉组1 355例。Meta分析结果显示:(1)安全性:局部组与静脉组相比,术后深静脉血栓(DVT)发生率[RR=0.76,95%CI(0.22,2.59),P=0.66]、肺栓塞(PE)发生率[RR=0.73,95%CI(0.08,7.02),P=0.79]、切口感染率[RR=1.26,95%CI(0.54,2.93),P=0.59]差异均无统计学意义;(2)有效性:局部组与静脉组对比,术后总失血量[WMD=16.75,95%CI(-30.07,63.57),P=0.48]、血红蛋白下降值[WMD=0.30,95%CI(0.02,0.58),P=0.03]、输血率[RR=1.37,95%CI(0.97,1.93),P=0.07]差异均无统计学意义。[结论]初次单侧全髋关节置换术局部应用氨甲环酸与静脉应用相比具有相当的安全性和有效性。

关键词(KeyWords)： 局部;关节腔;静脉;氨甲环酸;全髋关节置换术;Meta分析;安全性;有效性

Abstract:

Keywords:

基金项目(Foundation): 山东省自然科学基金(编号:ZR2015PH006)

作者(Author): 徐闯;刘明廷;孟涛;石辉;王建明;李健;杜长岭;

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参考文献(References)：

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