ECM修复兔桡骨缺损的实验研究Bone defect repair using allogenic ECM combined with chondrocytes in rabbits
刘俊宾;亓向同;
摘要(Abstract)：
[目的]研究自制的兔耳廓脱细胞软骨基质(extracellular cartilage matrix,ECM)修复骨缺损的特点及机理。[方法]采用新西兰大白兔共40只,随机分A、B两组,在其两侧桡骨干中段制作5 mm的骨缺损模型。右侧作为实验侧,缺损区A组植入脱细胞软骨基质复合自体培养骨髓干细胞,B组仅植入脱细胞软骨基质,左侧为空白对照。分别于2、4、6、10周处死动物,标本行放射学及组织学检查。[结果]X线及组织切片均证实复合体在6周时已有致密骨组织形成,10周时已有新生髓腔生成。[结论]表明兔耳廓脱细胞软骨基质与自体骨髓干细胞复合体有良好的成骨能力,有引导组织再生、防止骨不连作用。
关键词(KeyWords)： 骨缺损;骨移植;脱细胞软骨基质;软骨细胞
基金项目(Foundation):
作者(Author): 刘俊宾;亓向同;
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参考文献(References)：
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