血清D-二聚体在关节假体周围感染诊断中的意义Significance of serum D-dimer in the diagnosis of prosthetic joint infection
黄金承;王振;赵永强;强硕;金毅;郑稼;
摘要(Abstract)：
[目的]探讨血清D-二聚体在关节假体周围感染(prosthetic joint infection, PJI)诊断中的意义。[方法]回顾性分析本科2016年6月～2018年6月收治的80例患者,其中初次置换组33例,PJI分期翻修24例,无菌松动翻修术组23例。比较三组患者术前血清C-反应蛋白(CRP)、血沉(ESR)、D-二聚体等数据。[结果]三组患者一般资料比较差异无统计学意义(P>0.05)。PJI患者血清CRP、ESR水平显著高于初次关节置换及无菌性松动患者(P<0.05),PJI患者血清D-二聚体水平显著高于初次置换者(P<0.05),但与无菌性松动患者体内D-二聚体水平差异不具有统计学意义(P>0.05)。当以D-二聚体>0.85μg/L为PJI诊断标准时,血清CRP、ESR、D-二聚体诊断PJI的敏感性、特异性类似,差异无统计学意义(P>0.05)。当以D-二聚体>0.5μg/L为PJI诊断标准时,D-二聚体诊断PJI的敏感性与CRP及ESR类似(P>0.05),但特异性差于CRP及ESR,差异具有统计学意义(P<0.05)。[结论]与CRP、ESR相比,血清D-二聚体在PJI诊断中无明显优势。
关键词(KeyWords)： 关节假体周围感染;C反应蛋白;血沉;D-二聚体;诊断
基金项目(Foundation):
作者(Author): 黄金承;王振;赵永强;强硕;金毅;郑稼;
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参考文献(References)：
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