吴鹏飞;邓亮;谷文光;

• 1:哈尔滨医科大学附属临床第一医院骨科

摘要(Abstract)：

<正>半月板的功能具有承受负荷、震荡吸收、关节稳定、关节润滑和本体感觉等作用。生物力学研究表明半月板承受着至少50%的膝关节压力,90°左右的屈伸活动范围大约承受85%的负重[5]。半月板损伤采取部分切除或全切术后导致的半月板缺失,使得膝关节受力发生改变,是导致关节软骨破坏和退变发生的主要原因,使得如何处理损伤的半月板成为外科手术的难题。由于对半月板解剖和组织学的深入研究,过去20年间半月板损伤后修复得到飞速发展,尽管临床上取

关键词(KeyWords)： 半月板损伤;修复技术;细胞因子;组织工程学

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省教育厅海外学人基金项目(编号:1152hq31)

作者(Author): 吴鹏飞;邓亮;谷文光;

Email:

DOI:

参考文献(References)：

• [1]Sanchez-Adams J,Athanasiou KA.The knee meniscus:a complex tis-sue of diverse cells[J].Cell Mol Bioeng,2009,2:332-340.
• [2]Shiramizu K,Vizesi F,Bruce W,et al.Tibiofemoral contact areas andpressures in six high flexion knees[J].Int Orthop,2009,33:403-406.
• [3]顾羊林,王予彬.Treatment of meniscal injury:a current concept re-view[J].Chin J Traumatol,2010,13:370-376.
• [4]McNulty AL,Guilak F.Integrative repair of the meniscus:lessions AL,from in vitro studies[J].Biorheology,2008,45:487-500.
• [5]Lee SJ,Aadalen KJ,Malaviya P,et al.Tibiofemoral contact mechanicsafter serial medial meniscectomies in the human cadaveric knee[J].Am J Sports Med,2006,34:1334-1344.
• [6]Angele P,Johnstone B,Kujat R,et al.Stem cell based tissue engineer-ing for meniscus repair[J].J Biomed Mater Res A,2008,85:445-455.
• [7]Lubowitz JH,Verdonk PC,Reid JB3rd,et al.Meniscus allograft trans-plantation:a current concepts review[J].Knee Surg Sports TraumatolArthrosc,2007,15:476-492.
• [8]Feng H,Hong L,Geng XS,et al.Second-look arthroscopic evaluationof bucket-handle meniscus tear repairs with anterior cruciate ligamentreconstruction:67 consecutive cases[J].J Arthrosc Relat Surg,2008,24:1358-1366.
• [9]Choi NH,Kim TH,Victoroff BN,et al.Comparison of arthroscopic me-dial meniscal suture repair techniques:inside-out versus ail-insiderepair[J].Am J Sports Med,2009,37.2144-2151.
• [10]Turman KA,Diduch DR.Meniscal repair indications and techniques[J].J Knee Surg,2008,21:154-162.
• [11]JrvelS,Sihvonen R,Sirkeoja H,et al.Ail-inside meniscal repairwith bioabsorbable meniscal screws or with bioabsorbable meniscus ar-rows[J].Am J Sports Med,2010,38:2211-2218.
• [12]Koukoulias N,Papastergiou S,Kazakos K,et al.Clinical results of me-niscus repair with the meniscus arrow:a 4-to 8-year follow-up study[J].Knee Surg Sports Traumatol Arthrosc,2007,15:133-137.
• [13]Arnoczky SP,Warren RF.Microvasculature of the human meniscus[J].Am J Sports Med,1982,10:90-95.
• [14]Adams SB,Randolph MA,Gill TJ.Tissue engineering for meniscus re-pair[J].J Knee Surg,2005,18:25-30.
• [15]Gallacher PD,Gilbert RE,Kanes G,et al.White on white meniscaltears to fix or not to fix[J].Knee,2010,270-273.
• [16]Noyes FR,Barber-Westin SD.Repair of complex and avascular menis-cal tears and meniscal transplantation[J].J Bone Joint Surg Am,2010,92:1012-1029.
• [17]Arnoczky SP,Warren RF,Spivak JM.Meniscal repair using an exoge-neous fibrin clot.An experimental study in dogs[J].J Bone Joint SurgAm,1998,70:1209-1217.
• [18]Kamimura T,Kimura M.Repair of horizontal meniscal cleavage tearswith exogenous fibrin ciots[J].Knee Surg Sports Traumatol Arthrosc,2011,7:1154-1157.
• [19]Henning CE,Lynch MA,Clark JR.Vascularity for Healing of meniscsrepairs[J].J Arthros Relat Surg,2010,26:1368-1369.
• [20]Bhargava MM,Allia ET,Munrrell GA,et al.The Effect of cytokines onthe proliferation and migration of bovine meniscal cells[J].Am JSports Med,1999,27:636-643.
• [21]朱文辉,王予彬.膝关节半月板损伤后愈合的细胞分子生物力学研究进展[J].中国微创外科杂志,2008,8:752-754.
• [22]Connor WJ,Botti T.The use of growth factors in cartilage repair[J].Orthop Clin North Am,2000,31:399-410.
• [23]刘晓阳,汤继文,孙洪亮.碱性成纤维细胞生长因子对培养的半月板纤维软骨细胞的促进增殖作用[J].中国临床康复,2004,8:238-239.
• [24]王海玲,王宇,王新春.碱性成纤维细胞生长因子促进血管形成的研究进展[J].哈尔滨医科大学学报,2001,35:227-229.
• [25]Gunja NJ,Athanasiou KA.Additive and synergistic effects of bFGFand hypoxia on eporine meniscus cell-seeded PLLA scaffolds[J].JTissue Eng Regen Med,2010,4:115-122.
• [26]Wildemann B,Schmidmaier G,Brenner N,et al.Quantification locali-zation and expression of IGF-I and TGF-betal during growth factorstimulated fracture healing[J].Calcif Tissue Int,2004,74:388-397.
• [27]Steinert AF,Palmer GD,Capito R,et al.Genetically enhanced engi-neering of meniscus tissue using exvivo delivery of transforming growthfactor-betal complementary deoxyribonucleic acid[J].Tissue Eng,2007,13:2227-2237.
• [28]Izal I,Ripalda P,Carlos A,et al.In vitro healing of avascular meniscalinjuries with fresh and frozen plugs treated with TGF-13 and IGF-1 in sheep[J].J Clin Exp Pathol,2008,1:426-434.
• [29]Zhang HN,Leng P,Zhang J.Enhanced meniscal repair by overexpres-sion of hIGF-I in a full-thickness model[J].Clin Orthop,2009,467:3165-3174.
• [30]McNulty AL,Weinberg JB,Guilak F,et al.Inhibition of matrix metal-loproteinases enhances in vitro repair of the menbcus[J].Clin Or-thop,2009,467:1157-1567.
• [31]McNulty AL,Guilak F.Integrative repair of the meniscus:lessions fromin vitro studies[J].Biorheology,2008,3-4:487-500.
• [32]林勇,潘树栋.半月板运动损伤修复中组织工程材料的应用[J].中国组织工程研究与临床康复,2010,14:2237-2240.
• [33]Fox DB,Warnock JJ,Stoker AM,et al.Effects of growth factors on e-quine synovial fibroblasts seeded on synthetic scaffolds for avascularmeniscal tissue engineering[J].Res Vet Sci,201088:326-332.
• [34]黄埔尚峰.生物材料修复半月板损伤的特征[J].中国组织工程研究与临床康复,2010,14:9663-9666.
• [35]蔡贵泉,崔一民,陈晓东.骨髓间充质干细胞向纤维软骨细胞表型的诱导分化[J].中国组织工程研究与临床康复,2010,14:218-222.
• [36]Tan YB,Zhang YQ.Meniscus reconstruction through coculturing me-niscus cells with synovium-derived stem cells on small intestine sub-mucosa-a pilot study to engineer meniscus meniscus tissue constructs[J].Tissue Eng,2010,16:67-79.
• [37]付维力,王践云,万昌秀.组织工程半月板支架材料研究进展[J].生物医学工程学杂志,2010,27:458-462.
• [38]Valentin JE,Freytes DO,Grasman JM,et al.Oxygen diffusivity of bio-logic and synthetic scaffold materials for tissue engineering[J].J Bi-omed Mater Res A,2009,91:1010-1017.
• [39]张文林,刘丹平.软骨组织工程载体材料的研究与进展[J].中国组织工程研究与临床康复,2009,13:2329-2332.
• [40]穆继宏,胡蕴玉,毕龙,等.胶原-透明质酸钠-纤维蛋白胶复合去抗原松质骨支架的制备及特征[J].中国矫形外科杂志,2010,18:584-587.