石磊;王陵;张扬;刘帅;吕荣;王军;雷伟;

• 1:第四军医大学西京医院全军骨科研究所
• 2:第四军医大学统计教研室

摘要(Abstract)：

[目的]观察经过微弧氧化(micro-arc oxidation,MAO)表面处理的内植物是否能提高其在骨质疏松兔体内生物学表现。[方法]选用30只成年雌性新西兰大白兔,随机分为卵巢切除组(OVX组,n=20)和假手术组(Sham组,n=10),手术后2周,OVX组接受甲泼尼龙注射,Sham组接受生理盐水注射,6周后分别行双能X线检测两组的骨密度(bone mineral density,BMD)。确定OVX组骨质疏松模型建立成功后,兔胫骨两侧随机置入经MAO处理的及未处理的内植物,处理组为实验组,未处理组为对照组,术后12周处死动物,取材标本进行生物力学实验,显微CT检测以及组织学分析。[结果]OVX组的BMD显著低于Sham组(P<0.05)。内植物置入OVX组12周后,实验组的最大拔出力,能量吸收值,骨体积和组织骨密度,新骨形成率和骨接触率均优于对照组(P<0.05)。[结论]微弧氧化处理能够提高内植物在骨质疏松条件下的生物学表现,有利于增强内植物的稳定性。

关键词(KeyWords)： 微弧氧化;骨质疏松;内植物;内植物-骨界面;骨形成

Abstract:

Keywords:

基金项目(Foundation): 国家高技术研究发展计划(863计划)(编号:2007AA02Z468)

作者(Author): 石磊;王陵;张扬;刘帅;吕荣;王军;雷伟;

Email:

DOI:

参考文献(References)：

• [1]罗先正.骨质疏松性骨折及相关问题探讨[J].中国矫形外科杂志,2007,21:1627-1631.
• [2]Li D,Ferguson SJ,Beutler T,et al.Biomechanical comparison of thesandblasted and acid-etched and the machined and acid-etched tita-nium surface for dental implants[J].J Biomed Mater Res,2002,60:325-332.
• [3]De Groot K,Geesink R,Klein CPAT,et al.Plasma sprayed coatings ofhydroxylapatite[J].J Biomed Mater Res,1987,21:1375-1381.
• [4]Zhao Z,Wen S.Direct preparation of CaTi4(PO4)6 coatings on thesurface of titanium substrate by micro arc oxidation[J].J Mater SciMater Med,2007,18:2275-2281.
• [5]Li LH,Kong YM,Kim HW,et al.Improved biological performance ofTi implants due to surface modification by micro-arc oxidation[J].Biomaterials,2004,25:2867-2875.
• [6]Slaets E,Carmeliet G,Naert I,et al.Early trabecular bone healing a-round titanium implants:a histologic study in rabbits[J].J Periodon-tol,2007,3:510-517.
• [7]Ohtsuki C,Lids H,Hayakawa S,et al.Bioactivity of titanium treatedwith hydrogen peroxide solution containing metal chlorides[J].J Bi-omed Mater Res,1997,1:39-47.
• [8]Reitman CA,Nguyen L,Fogel GR.Biomeehanical evaluation of rela-tionship of screwpullout strength,insertional torque,and bone mineraldensity in the cervical spine[J].J Spinal Disord Tech,2004,4:306-311
• [9]Geetha M,Singh AK,Asokamani R,et al.Ti based biomaterials,theultimate choice for orthopaedic implants-a review[J].Prog Mater Sci,2009,54:397-425.
• [10]Zhu X,Chen J,Scheideler L,et al.Effects of topography and composi-tion of titanium surface oxides on osteoblast responses[J].Biomateri-als,2004,25:4087-4103.
• [11]Sul YT,Johansson C,Byon E,et al.The bone response of oxidized bio-active and non-bioactive titanium implants[J].Biomaterials,2005,26:6720-6730.
• [12]Li LH,Kong YM,Kim H,et al.Improved biological performance of Tiimplants due to surface modification by micro-arc oxidation[J].Bio-materials,2004,14:2867-2875.
• [13]Orsini G,Assenza B,Scarano A,et al.Surface analysis of machinedversus sandblasted and acid-etched titanium implants[J].Im J OralMaxillofac Implants,2000,6:779-784.
• [14]Kunzler TP,Drobek T,Schuler M,et al.Systematic study of osteoblastand fibroblast response to roughness by means of surface-morphologygradients[J].Biomaterials,2007,13:2175-2182.
• [15]Frosch KH,Dresing K.Autologous osteoblasts enhance osseointegrationof porous titanium implants[J].J Orthopaedic Res,2003,11:213-223.
• [16]Schwartz Z,Nasazky E,Boyan BD.Surface microtopography regulatesosteointegration:the role of implant surface microtopography in os-teointegration[J].Alpha Omegan,2005,2:9-19.