邝冠明;邱伟鹏;林凤年;曲广运;吕维加;

• 1:香港大学矫形与创伤外科学系

摘要(Abstract)：

近10年来,应用软组织移植物行前交叉韧带重建术越来越普遍。手术的远期疗效主要取决于肌腱移植物能否在骨隧道内达到坚强的腱-骨愈合。但是,目前面临的问题是肌腱移植物在骨隧道内获得腱-骨愈合所需要的时间相当长。研究发现,在腱-骨界面局部应用生物骨传导性的骨水泥能有效地促进肌腱移植物的骨愈合。这类骨水泥主要是磷酸钙。本文就生物骨传导性骨水泥促进前交叉韧带重建术腱-骨愈合的研究进展作一综述。

关键词(KeyWords)： 前交叉韧带;移植物;愈合;肌腱;隧道

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 邝冠明;邱伟鹏;林凤年;曲广运;吕维加;

Email:

DOI:

参考文献(References)：

• [1]Gorden M,stein M.Anterior cruciate ligament injuries[M]∥GarrickJ.Orthopaedic knowledge update:sports Medicine.3ed.Rosemont:A-merican Academy of Orthopaedic Surgeons,2004:169-181.
• [2]Beynnon BD,Johnson RJ,Abate JA,et al.Treatment of anterior cruci-ate ligament injuries,part 2[J].Am J Sports Med,2005,33:1751-1767.
• [3]Beynnon BD,Johnson RJ,Abate JA,et al.Treatment of anterior cruci-ate ligament injuries,part I[J].Am J Sports Med,2005,33:1579-1602.
• [4]Marrale J,Morrissey MC,Haddad FS.A literature review of autograftand allograft anterior cruciate ligament reconstruction[J].Knee SurgSports Traumatol Arthrosc,2007,15:690-704.
• [5]Bartlett RJ,Clatworthy MG,Nguyen TN.Graft selection in reconstruc-tion of the anterior cruciate ligament[J].J Bone Joint Surg Br,2001,83:625-634.
• [6]Duquin TR,Wind WM,Fineberg MS,et al.Current trends in anteriorcruciate ligament reconstruction[J].J Knee Surg,2009,22:7-12.
• [7]Williams RJ,Hyman J,Petrigliano F,et al.Anterior cruciate ligamentreconstruction with a four-strand hamstring tendon autograft.Surgicaltechnique[J].J Bone Joint Surg Am,2005,1:51,66.
• [8]Charlick DA,Caborn DN.Technical note:alternative soft-tissue graftpreparation technique for cruciate ligarnent reconstruction[J].Arthro-scopy,2000,16:20.
• [9]Fabbriciani C,Mulas PD,Ziranu F,et al.Mechanical analysis of fixa-tion methods for anterior cruciate ligament reconstruction with ham-string tendon graft.An experimental study in sheep knees[J].Knee,2005,12:135-138.
• [10]Adam F,Pape D,Schiel K,et al.Biomechanical properties of patellarand hamstring graft tibial:fixation techniques in anterior cruciate liga-ment reconstruction:experimental study with roentgen stereometric a-nalysis[J].Am J Sports Med,2004,32:71-78.
• [11]Brand J Jr,Weiler A,Caborn DN,et al.Graft fixation in cruciate liga-ment reconstruction[J].Am J Sports Med,2000,28:761-774.
• [12]Sherman OH,Banffy MB.Anterior cruciate ligament reconstruction:which graft is best[J].Arthroscopy,2004,20:974-980.
• [13]Tom JA,Rodeo SA.Soft tissue allografts for knee reconstruction insports medicine[J].Clin Orthop Relat Res,2002:135-156.
• [14]Nikotaou VS,Efstathopoulos N,Wredmark T.Hamstring tendons re-generation after ACLreconstruction:an overview[J].Knee Surg SportsTraumatol Arthrosc,2007,15:153-160.
• [15]Lawhorn KW,Howell SM.Principles for using hamstring tendons foranterior cruciate ligament reconstruction[J].Clin Sports Med,2007,26:567-585.
• [16]Hamer CD,Olson E,Irrgang JJ,et al.Allograft versus autograft anteriorcruciate ligament reconstruction:3-to 5-year outcome[J].Clin OrthopRelat Res,1996:134-144.
• [17]Goradia VK,Rochat MC,Kida M,et al.Natural history of a hamstringtendon autograft used for anterior cruciate ligament reconstruction in asheep model[J].Am J Sports Med,2000,28:40-46.
• [18]Ekdahl M,Wang JH,Ronga M,et al.Graft healing in anterior cruciateligament reconstruction[J].Knee Surg Sports Traumatol Arthrosc,2008,16:935-947.
• [19]Weiler A,Hoffmann RF,Bail HJ,et al.Tendon healing in a bone tun-nel.PartⅡ:histologic analysis after biodegradable interference fit fix-ation in a model of anterior cruciate ligament reconstruction in sheep[J].Arthroscopy,2002,18:124-135.
• [20]Rodeo SA,Arnoczky SP,Torzilli PA,et al.Tendon-healing in a bonetunnel.A biomechanical and histological study in the dog[J].J BoneJoint Surg Am,1993,75:1795-803.
• [21]Segawa H,Koga Y,Omori G,et al.Influence of the femoral tunnel lo-cation and angle on the contact pressure in the femoral tunnel in ante-rior cruciate ligament reconstruction[J].Am J Sports Med,2003,31:444-448.
• [22]Yoshiya S,Nagano M,Kurosaka M,et al.Graft healing in the bonetunnel in anterior cruciate ligament reconstruction[J].Clin OrthopRelat Res,2000,1:278-286.
• [23]Goradia VK.Tendon healing in a bone tunnel.Parts I andⅡ[J].Ar-throscopy,2003,19:111.
• [24]Rodeo SA,Suzuki K,Deng XH,et al.Use of recombinant human bonemorphogenetic protein-2 to enhance tendon healing in a bone tunnel[J].Am J Sports Med,1999,27:476-488.
• [25]Liu SH,Panossian V,al-Shaikh R,et al.Morphology and matrix com-position during early tendon to bone healing[J].Clin Orthop RelatRes,1997:253-260.
• [26]Shelbourne KD,Carr DR.Combined anterior and posterior cruciateand medial collateral ligament injury:nonsurgical and delayed surgicaltreatment[J].Instr Course Lect,2003,52:413-418.
• [27]Martinek V,Imhoff AB.Revision of failed anterior cruciate ligamentreconstruction[J].Orthopade,2002,31:778-784.
• [28]Denti M,Lo VD,Bait C,et al.Revision anterior cruciate ligament re-construction:causes of failure,surgical technique,and clinical results[J].Am J Sports Med,2008,36:1896-1902.
• [29]Krych AJ,Jackson JD,Hoskin TL,et al.A meta-analysis of patellartendon autograft versus patellar tendon allograft in anterior cruciate lig-ament reconstruction[J].Arthroscopy,2008,24:292-298.
• [30]Kuang GM,Yau WP,Lu WW,et al.Osteointegration of soft tissuegrafts within the bone tunnels in anterior cruciate ligament reconstruc-tion can be enhanced[J].Knee Surg Sports Traumatol Arthrosc,2009,DOI 10.1007/s 00167-009-0910-1
• [31]Steiner ME,Murray MM,Rodeo SA.Strategies to improve anterior cru-ciate ligament healing and graft placement[J].Am J Sports Med,2008,36:176-189.
• [32]Hak DJ.The use of osteoconductive bone graft'sibstitutes in ortho-paedic trauma[J].J Am Acad Orthop Surg,2007,15:525-536.
• [33]Kokubo T,Kim HM,Kawashita M.Novel bioactive materials with differentmechanical properties[J].Biomaterials,2003,24:2161-2175.
• [34]LeGeros RZ.Properties of osteoconductive biomaterials:calcium phos-phates[J].Clin Orthop Relat Res,2002:81-98.
• [35]LeGeros RZ.Calcium phosphate-based osteoinductive materials[J].Chem Rev,2008,108:4742-4753.
• [36]Bohner M,Baroud G.Injectability of calcium phosphate pastes[J].Biomaterials,2005,26:1553-1563.
• [37]Tien YC,Chih TT,Lin JH,et al.Augmentation of tendon-bone healingby the use of calcium-phosphate cement[J].J Bone Joint Surg Br,2004,86:1072-1076.
• [38]Mutsuzaki H,Sakane M,Nakajima H,et al.Calcium-phosphate-hy-bridized tendon directly promotes regeneration of tendon-bone insertion[J].J Biomed Mater Res A,2004,70:319-327.
• [39]Huangfu X,Zhao J.Tendon-bone healing enhancement using inject-able tricalcium phosphate in a dog anterior cruciate ligament recon-struction model[J].Arthroscopy,2007,23:455-462.
• [40]Waselau M,Samii VF,Weisbrode SE,et al.Effects of a magnesiumadhesive cement on bone stability and healing following a metatarsalosteotomy in horses[J].Am J Vet Res,2007,68:370-378.
• [41]Gulotta LV,Kovacevic D,Ying L,et al.Augmentation of tendon-to-bone healing with a magnesium-based bone adhesive[J].Am J SportsMed,2008,36:1290-1297.