周围神经在缓慢肢体延长中的形态学观察Morphological observation on the peripheral nerve after slow limb lengthening
王春妹;舒衡生;邵珩;赵志明;李云生;
摘要(Abstract)：
[目的]观察兔缓慢肢体延长中周围神经损伤及其自然修复过程的组织形态和超微结构变化。[方法]35只日本大耳白兔,胫骨延长长度为1 cm后,分别于停止延长时,停止延长后1、2、4、8周取材,以光学显微镜和透射电镜观察各时相胫神经延长区组织形态及超微结构的变化。[结果]延长1 cm时,光镜下神经纤维排列紊乱,部分郎飞氏结区增宽,髓鞘肿胀,可见神经纤维扩展性脱髓鞘;电镜下神经纤维髓鞘板层结构疏松,可见空泡状髓鞘变性,肿胀压迫轴突。延长后7 d,光镜下神经纤维除明显损伤性病变外已出现轻度修复性变化;电镜下可见有新形成的髓鞘。以后随着时间的延长,神经损伤逐渐自我修复,至8周时基本恢复正常,但仍可见有新生的髓鞘。[结论]缓慢肢体延长过程中周围神经的亚临床损害是暂时的、可逆的,并且在神经损伤的同时其自然修复就已开始。
关键词(KeyWords)： 肢体延长;胫神经;电镜;兔
基金项目(Foundation): 天津医科大学重点学科资助基金项目(编号:2009XK04)
作者(Author): 王春妹;舒衡生;邵珩;赵志明;李云生;
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DOI:
参考文献(References)：
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