骨关节炎软骨下骨重建及骨保护素的研究进展
汪鑫;黄明;
摘要(Abstract)：
<正>传统观念中,骨关节炎的主要特征是软骨病变,而对软骨下骨病变不够重视。自从1972年,Radin等首次提出关节退变的发病机制可能起始于软骨下骨,越来越多的新证据提示,软骨下骨与骨关节炎的疾病进展关系紧密。软骨下骨发生异常的骨重建(软骨下骨硬化、骨赘形成)是骨关节炎的主要特征之
关键词(KeyWords)： 骨关节炎;软骨下骨;骨重建;骨保护素
基金项目(Foundation):
作者(Author): 汪鑫;黄明;
Email:
DOI:
参考文献(References)：
- [1]Felson DT,Neogi T.Osteoarthritis:is it a disease of cartilage or of bone[J].Arthritis Rheum,2004,2:341 -344.
- [2]Bijlsma J,Berenbaum F,Lafeber F.Osteoarthritis:an update with relevance for clinical practice[J],Lancet,20II,377:2115 -2126.
- [3]Mansell JP,Collins C,Bailey AJ.Bone,not cartilage,should be the major focus in osteoarthritis[J].Nat Clin Pract Rheumatol,2007,6: 306-307.
- [4]Imhof H,Sulzbacher I,Grampp S,et al.Subchondral bone and cartilage disease a rediscovered functional unit[J].Invest Radiol,2000, 35:581 -588.
- [5]Madry H,van Dijk CN,Mueller - Gerbl M.The basic science of the subchondral bone[J].Knee Surg Sports Traumatol Arthrosc,2010, 18:419-433.
- [6]Raynauld JP,Martel - Pelleder J,Berthiaume MJ,et al.Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24 - month period[J].Ann Rheum Dis, 2008,67:683 -688.
- [7]Miriam B,Laura L,Jorge ARB,et al.Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis[J].Arthr Res Ther,2010,4:152.
- [8]Anderson -MacKenzie JM,Quasnichka HL,Starr RL,et al.Fundamental subchondral bone changes in spontaneous knee osteoarthritis[J].Int J Biochem Cell Biol,2005,37:224-236.
- [9]Interna F,Sniekers YH,Weinans H,et al.Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis[J].J Bone Miner Res,2010,25:1650 - 1657.
- [10]Bettica P,Cline G,Hart DJ,et al.Evidence for increased bone resorption in patients with progressive knee osteoarthritis;longitudinal results from the Chingford study[J].Arthritis Rheum,2002,46:3178 -3184.
- [11]Hayami T,Pickarski M,Zhuo Y,et al.Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis [J].Bone,2006,38:234-243.
- [12]Kwan Tat S,Pelletier JP,Ruiz Velasco C,et al.New perspective in osteoarthritis:the OPG and RANKL system as a potential therapeutic target[J].Keio J Med,2009,1:29 - 40.
- [13]Ding M.Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues[J].Acta Orthop Suppl,2010,340:1 -53.
- [14]Kwan Tat S,Padrines M,Theoleyre S,et al.IL - 6,RANKL,TNF-alpha /IL - 1:interrelations in bone resorption pathophysiology[J]. Cytokine Growth Factor Rev,2004,15:49 -60.
- [15]Simonet W.S,Lacey DL,Dunstan CR.et al.Osteoprotegerin:a novel secreted protein involved in the regulation of bone density[J].Cell, 1997,89:309-319.
- [16]Troen BR.Molecular mechanisms underlying osteoclast formation and activation[J].Exp Gerontol,2003,38:605 -614.
- [17]Kadri A,Ea HK.Bazille C,et al.Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis[J].Arthritis Rheum,2008,58:2379 - 2386.
- [18]Kwan Tat S,Pelletier JP.Lajeunesse D,et al.The differential expression of osteoprotegerin(OPG) and receptor activator of nuclear factor kappaB ligand(RANKL) in human osleoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells [J].Clin Exp Rheumatol,2008,26:295 -304.
- [19]Meulenbelt I,Kloppenburg M,Kroon HM,et al.Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites.The GARP study [J].Osteoarthritis Cartilage,2007,15:379 -385.