高玉镭;张寅权;宋方龙;蒋大伟;王一;康一凡;

• 1:上海长海医院骨科

摘要(Abstract)：

[目的]研究膝骨性关节炎患者行人工全膝关节置换术时进行滑膜切除与否对术后感染的影响。[方法]选择2008年~2012年860例符合原发性膝骨关节炎诊断标准的患者,年龄48~82岁,分为两组:420例关节置换同时进行滑膜切除,440例未进行滑膜切除。随访3~7年,平均4.8年。观察和测定手术时间,引流量,术前和术后1、3 d,2、6、12周和1年血沉(ESR)、C反应蛋白(CRP)、白细胞总数和感染率评价膝关节术后临床效果。采用VAS评分和AKSS评分评价手术效果。[结果]两组患者术前各项临床指标差异均无统计学意义,基线基本相同。手术时间滑膜切除组较长(76±15)min,非切除组(65±12)min,P<0.001,伤口引流量滑膜切除组(285±105)ml,未切除组(245±103)ml,P<0.001。术后滑膜未切除组患者血液中ESR、CRP水平高于切除组,术后2周CRP恢复到术前水平,而ESR缓慢降低直至术后6周接近正常水平。术后两组患者白细胞总数,未切除组偏高,但差异无统计学意义。术后两组患者VAS评分和AKSS评分差异无统计学意义。在平均4.8年的随访中,切除组出现表浅感染3例,深部感染4例,未切除组表浅感染2例,无深部感染患者。[结论]人工全膝关节置换术滑膜切除组手术时间及伤口引流量均高于未切除组,未切除组术后白细胞总数、ESR,CRP偏高,但感染率低,因此推测膝关节滑膜在抗感染中发挥作用。

关键词(KeyWords)： 滑膜切除;膝关节;置换;感染

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 高玉镭;张寅权;宋方龙;蒋大伟;王一;康一凡;

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参考文献(References)：

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