股骨头缺血性坏死药物治疗进展
帕力哈提·白克吐尔逊;彭昊;
摘要(Abstract):
<正>股骨头缺血性坏死(ANFH)是临床常见病,全世界现有股骨头坏死患者2 000多万例,其中我国有500~750万命名[1],目前仍然缺乏十分有效的治疗手段,早期治疗和预防是治疗ANFH的关键。目前国内外已有了一些ANFH药物治疗的研究并取得了一些进步。本文就ANFH药物治疗进展作
关键词(KeyWords): 股骨头坏死;药物治疗
基金项目(Foundation):
作者(Author): 帕力哈提·白克吐尔逊;彭昊;
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DOI:
参考文献(References):
- [1]刘铁钢,陈卫衡.非创伤性股骨头坏死的流行病学研究进展[J].医学综述,2009,17.
- [2]Kiyokazu F,Rieko K,Harumichi S,et al.Glucocorticoid induces mi-cro-fat embolism in the rabbit:a scanning electron microscopicstudy[J].Journal Orthop Res,2006,1:675-683.
- [3]Kabata T,Kubo T,Matsumoto T,et al.Onset of steroid-induced os-teonecrosis in rabbits and its relationship to hyperlipaemia and in-creased free fatty acids[J].Rheumatology,2005,44:1233-1237.
- [4]Muhammad A,Matas AJ,Michael K,et al.Does statin usage reducethe risk of corticosteroid-related osteonecrosis in renal transplantpopulation[J].Orthopedic Clinics of North America,2009,2:235-239.
- [5]Nishida K,Yamamoto T,Motomura G,et al.Pitavastatin may reducerisk of steroid-induced osteonecrosis in rabbits:a preliminary histo-logical study[J].Clin Orthop Relat Res,2008,5:1054-1058.
- [6]Kentaro I,Yutaka O,Yasunoro K,et al.Effect of simvastatin on ster-oid-induced osteonecrosis evidenced by the serum lipid level andhepatic cytochrome P4503A in a rabbit model[J].J Orthop Sci,2008,13:463-468.
- [7]Jones LC,Mont MA,Le TB,et al.Procoagulants and osteonecrosis[J].J Rheumatology,2003,4:783-791.
- [8]Nagasawa K,Taya Y,Koarada S,et al.Prevention of steroid-in-duced osteonecrosis of femoral head in systemic lupus erythematosusby anti-coagulant[J].Lupus,2006,6:354-357.
- [9]Glueck,Freiberg,Sieve L,et al.Enoxaparin prevents progression ofstages I and II osteonecrosis of the hip[J].Clin Orthop Relat Res,2005,435:164-170.
- [10]Matsumoto K,Ichiseki.Oxidative stress on idiopathic osteonecrosis[J].Clinical Calcium,2007,6:887-891.
- [11]Ichiseki,Matsumoto,Nishino,et al.Oxidative stress and vascularpermeability in steroid-induced osteonecrosis model[J].oumai ofOrthopaedic Science,2004,5:509-515.
- [12]Ramachandran M,Ward K,Brown RR,et al.Intravenous bisphos-phonate therapy for traumatic osteonecrosis of the femoral head inadolescents[J].J Bone Joint Surg Am,2007,8:1727-1734.
- [13]Cardozo,Andrade,Santiago.The use of bisphosphonate in the treat-ment of avascular necrosis:a systematic reyiew[J].Clin Rheumatol,2008,6:685-688.
- [14]Iwamoto J,Sato Y,Takeda T,et al.Hip fracture protection by alendr-onate treatment in postmenopausal women with osteoporosis:a reviewof the literature[J].Clinical Interventions in Aging,2008,3:483-489.
- [15]Nishii T,Sugano N,Miki H,et al.Does alendronate prevent collapsein osteonecrosis of the femoral head[J].Clin Orthop Relat Res,2006,443:273-279.
- [16]Kaneshiro Y,Oda Y,Iwakiri K,et al.Low hepatic cytochrome P4503A activity is a risk for corticosteroid-induced Osteonecrosis[J].Clinical Pharmacology&Therapeutics(New York,NY,UnitedStates),2006,4:396-402.
- [17]Toshiaki M,Kentaro I,Yutaka O,et al.Increased hepatic cytochromeP4503A activity decreases the risk of developing steroid-inducedosteonecrosis in a rabbit model[J].J Orthop Res,2008:91-95.
- [18]Johannesen J,Briody J,McQuade M,et al.Systemic effects of zole-dronic acid in children with traumatic femoral head avascular necrosisand Legg-Calve-Perthes disease[J].Bone,2009,5:898-902.
- [19]David MR,Jean-Pierre D,Kenneth S,et al.Zoledronic acid andrisedronate in the prevention and treatment of glucocorticoid-in-duced osteoporosis(HORIZON):a multicentre,double-blind,double-dummy,randomised controlled trial[J].Lancet,2009,373:1253-1263.
- [20]Friedl G,Radl R,Stihsen C,et al.The Effect of a single infusion ofzoledronic acid on early implant migration in total hip arthroplasty arandomized,double-blind,controlled,trial[J].J Bone Joint Sur-gery-American Volume,2009,2:274-281.
- [21]Zhang G,Ling Q,Sheng H,et al.A novel semisynthesized small mol-ecule icaritin reduces incidence of steroid-associated osteonecrosiswith inhibition of both thrombosis and lipid-deposition in a dose-dependent manner[J].Bone,2009,44:345-356.
- [22]Qi ZX,Chen L.Effect of Chinese drugs for promoting blood circula-tion and eliminating blood stasis on vascular endothelial growth fac-tor expression in rabbits with glucocorticoid-induced ischemic nec-rosis of femoral head[J].J Tradit Chin Med,2009,2:137-40.
- [23]Wang YS,Yin L,Li YB,et al.Preventive effects of puerarin on alco-hol-induced osteonecrosis[J].Clin Orthop,2008,466:1059-1067.
- [24]Ikemura S,Yamamoto T,Nishida K,et al.Gender difference in thedevelopment of steroid-induced osteonecrosis in rabbits[J].Rheu-matology,2010,49:1128-1132.
- [25]Zhang G,Qin L,Sheng H,et al.Epimedium-derived phytoestrogenexert beneficial effect on preventing steroid-associated osteonecro-sis in rabbits with inhibition of both thrombosis and lipid-deposi-tion[J].Bone,2007,40:685-692.
- [26]Meizer R,Radda C,Stolz G,et al.MRI-controlled analysis of 104patients with painful bone marrow edema in different joint localiza-tions treated with the prostacyclin analogue iloprost[J].Wien KilnWochenschr,2005,7-8:278-286.
- [27]Alessandra B,Francesca P,Bruce B,et al.Protective effect ofgenistein aglycone on the development of osteonecrosis of the femoralhead and secondary osteoporosis induced by methylprednisolone inrats[J].J Endocrinology,2009,201:321-328.
- [28]Popov IV,Bolabovko AE,Nikitiuk IE,et al.Reparative bone regenera-tion after aseptic necrosis of the femoral head as influenced by i-chloromethylsilatrane treatment[J].Morfologiia,2005,5:64-66.
- [29]Masaaki K,Mikihiro F,Kenji AT,et al.Vitamin E prevents steroid-induced osteonecrosis in rabbits[J].Acta Orthopaedica,2010,1:154-160.
- [30]王昌兴,沈建国,姜滔,等.持续局部丹参和肝素灌注治疗股骨头坏死疗效分析[J].中国骨伤,2010,5.
- [31]Motomura G,Yamamoto T,Miyanishi K,et al.Combined effects ofan anticoagulant and a lipid-lowering agent on the prevention ofsteroid-induced osteonecrosis in rabbits[J].Arthritis Rheum,2004,10:3387-3391.
- [32]Pengde K,Hong G,Fuxing P,et al.Effects of an anticoagulant and alipid-lowering agent on the prevention of steroid-induced osteone-crosis in rabbits[J].International Journal of Experimental Patholo-gy,2010,3:235-243.