沈是铭,毛宾尧

• 1:宁波市第一医院骨科!宁波市骨科研究所
• 2:315010
• 3:宁波市第一医院骨科!宁波市骨科研究所
• 4:315010

摘要(Abstract)：

目的 :综述关节软骨自分泌调节的进展。方法 :通过研究在局部环境中 ,关节软骨的主要自分泌因子在细胞分子水平对关节软骨的代谢、修复等方面的调控。结果 :IGF 1,TGF β ,FGFs和BMPs是病损致软骨基质降解时调节关节软骨细胞表型的最重要自分泌因子。PTHrP为软骨自分泌 /旁分泌因子 ,在介调软骨损伤和修复过程中的细胞变化起作用。结论 :关节软骨依靠大量的自分泌因子维持软骨细胞的表型和正常基质的代谢 ,因子间的协同刺激和反馈调节 ,是关节软骨细胞功能的最重要局部调节者。

关键词(KeyWords)： 关节软骨;软骨细胞;自分泌;调节

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 沈是铭,毛宾尧

Email:

DOI:

参考文献(References)：

• 〔1〕　RogachefskyRA ,DeanDD ,HowellDS ,etalTreatmentofcanineosteoarthritiswithinsulin likegrowthfactor 1(IGF 1)andsodiumpentosanpolysulfate[J] .OsteoarthritisCarti lage ,1993 ,1:10 5～ 114 .
• 〔2〕　TrippelSB ,CorvolMT ,DumontierMF ,etal.Effectofso matomedin C/insulin likegrowthfactorIandgrowthhor moneonculturd growthplateandarticularchondrocytes[J] .PediatrRes ,1989,2 5 :76～ 82 .
• 〔3〕　HulthA ,JohnellO ,MiyazonoK ,etal.Effectoftransform ing growthfactor betaandplatelet derivedgrowthfactor BBonarticularcartilageinrats[J] .JOrthopres ,1996,14 :5 47～ 5 5 3 .
• 〔4〕　OlneyRC ,TsuchiyaK ,WilsonDM ,etal.Chondrocytesfromosteoarthriticcatilagehaveincreasedexpressionofinsulin likegrowthfactorI(IGF 1)andIGF bindingprotein 3 (IGFBP 3 )and 5 ,butnotIGF ⅡorIGFBP 4[J] .ClinEndocrinolMetab ,1996,81:10 963～ 110 3 .
• 〔5〕　JakowlewSB ,DillardPJ ,WinokurTS ,etal.Expressionoftransforminggrowthfactor betas 1 4inchickenembryochondrocytesandmyocytes[J] .DevBiol ,1991,14 3 :13 5～14 8.
• 〔6〕　KingsleyDM .TheTGF betasuperfamily :Newmembers ,newreceptors ,andnewgenetictestsoffunctionindiffere ntorganisms[J] .GenesDev ,1994,8:13 3～ 14 6.
• 〔7〕　BuckwalterJA ,MankinHJ .ArticularcartilagePartITis suedesignandchondrocyte matrixinteractions :PartⅡDe generationandosteoarthrosis ,repair ,regeneration ,andtransplantation[J] .JBoneJointSurg ,1997,79A :60 0～63 2 .
• 〔8〕　LagnaG ,Hata ,A ,hemmatiBrivanlouA ,etal.PartnershipbetweenDPC4andSMAD proteinsinTGF betasignallingpathways[J] .Nature ,1996,3 83 :83 2～ 83 6.
• 〔9〕　VilligerPM ,LotzM .DifferentialexpressionofTGFbetaisoformsbyhumanarticularchondrocytesinresponsetogrowthfactors[J] .JCellPhysiol,1992 ,15 1:3 18～ 3 2 5
• 〔10〕VilligerPM ,KusariAB ,DijkeP ,etal.IL 1betaandIL 6selectivelyinducetransforminggrowthfactor betaisoformsinhumanarticularchondrocytes[J] .Jimmunol,1993 ,15 1:3 3 3 7～ 3 3 4 4.
• 〔11〕BoivinGP ,OTooleBA ,OrmsbyIE ,etal.Onsetandpro gressionofpathologicallesionsintransforminggrowthfac tor betal deficientmice[J] .AmJpathol,1995 ,14 6:2 76～2 88.
• 〔12〕KaartinenV ,VonckenJW ,ShulerC ,etal.AbnormallungdevelopmentandcleftpalateinmicelackingTGF beta 3in dicatesdefectsofepithelial mesenchymalinteraction[J] .NatGenet ,1995 ,11:415～ 42 1.
• 〔13〕SahRL ,TrippelSB ,GrodzinskyAJ .Differentialeffectsofserum ,insulin like growthfactor l ,andfibroblast growthfactor 2onthemaintenanceofcartilagephysicalpropertiesduringlong termculture[J] .JOrthopRes ,1996,14 :44～5 2 .
• 〔14〕StoilovI ,KilpatrickMW ,TsipourasP .AcommonFGFR3mutationispresentinachondroplasiabutnotinhypochon droplasia[J] .AmJMedGenet ,1995 ,5 5 :12 7～ 13 3 .
• 〔15〕HunzikerEB ,RosenbergLC .Repairofpartial thicknessde fectsinarticularcartilage :Cellrecruitmentfromthesynovialmembrance[J] .JBoneJointSurg ,1996,78A :72 1～ 73 3 .
• 〔16〕Hemmati brivanlouA ,MeltonD .Vertebrateembryoniccelswillbecomenervecellsunlesstoldotherwise[J] .Cell,1997,88:13～ 17.
• 〔17〕LiuF ,VenturaF ,DoodyJ ,etal .HumantypeⅡreceptorforbonemorphogenicproteins(BMPs) :extensionofthetwo kinasereceptormodeltotheBMPs[J] .MolCellBiol,1995 ,15 :3 4 79～ 3 4 86.
• 〔18〕KesslerE ,TakaharaK ,BiniaminovL ,etal .Bonemorpho geneticprotein 1:ThetypeIprocollagenC proteinase[J] .Science ,1996,2 71:3 60～ 3 62 .
• 〔19〕LuytenFP ,YuYM ,YanagishitaM ,etal .Naturalbovineosteogeninandrecombinanthumanbonemorphogeneticprotein 2Bareequipotentinthemaintenanceofproteogly cansinbovinearticularcartilageexplntcultures[J] .JBioChem ,1992 ,2 67:3 691～ 3 695 .
• 〔2 0〕LanskeB ,KaraplisAC ,LeeK ,etal .PTH/PTHrPreceptorinearlydevelopmentandindianhedgehog regulatedbonegrowth[J] .Science ,1996,2 73 :663～ 666.
• 〔2 1〕VortkampA ,LeeK ,LanskeB ,etal.RegulationofrateofcartilagedifferentiationbyindianhedgehogandPTH relat edprotein[J] .Science ,1996,2 73 :613～ 62 2 .
• 〔2 2〕AmizukaN ,WarshawskyJE ,HendersonD ,etal.Parathy roidhormonerelatedpeptide depletedmiceshowabnormalepiphysealcartilagedevelopmentandalteredendochondralboneformation[J] .JCellBiol,1994,12 6:1611～ 162 3 .
• 〔2 3〕TsukazakiT ,OhtsuruA ,EnomotoH ,etal.Expressionofparathyroidhormone relatedproteininratarticularcartilage[J] .CalcifTissueInt,1995 ,5 7:196～ 2 0 0 .
• 〔2 4〕TsukazakiT ,OhtsuruA ,NambaH ,etal .Parathtyroidhor mone relatedprotein(PTHrP)actioninratarticularchon drocytes:ComparisonofPTH ( 1～ 3 4 ) ,PTHrP( 1～ 14 1) ,PTHrp( 10 0～ 114 )andantisenseoligonucleotidesagainstPTHrP[J] .JEndocrinol,1996,15 0 :3 5 9～ 3 68.
• 〔2 5〕VerschurePJ ,JoostenLA ,vanderKraanPM ,etal .Re sponsivenessofarticularcartilagefromnormalandinflamedmouseknejointstovariousgrowthfactors[J] .AmRheumDis ,1994,5 3 :45 5～ 460 .
• 〔2 6〕HenrotinYE ,DeGrooteDD ,LabasseAH ,etal .EffectsofexogenousIL 1beta ,TNFalpha ,IL 6,IL 8andLIFoncy tokineproductionbyhumanarticularchondrocytes[J] .Os teoarthritisCartilage ,1996,4:163～ 173 .