窦永峰;房清敏;王志刚;孙兆忠;仲江波;

• 1:山东滨州医学院附属医院骨科

摘要(Abstract)：

[目的]研究TGF-β1抗体(transforming growth factor-β1 antibody,TGF-β1Ab)复合生物蛋白胶(fi-brin glue,FG)预防鞘管区屈肌腱粘连的作用和对肌腱愈合的影响。[方法]成年雄性来亨鸡72只随机平均分为4组,每组18只。左足第3趾趾深屈肌腱横断,四股交叉缝合肌腱,鞘管未缝合。按鞘管区给药分为4组:A组TGF-β1Ab、B组FG、C组TGF-β1Ab+FG、D组生理盐水。仅术中注入一次药物。术后1、3、8周,每组各取6只鸡第3趾行大体及组织学观测。[结果]大体观察:术后1、3、8周肌腱粘连程度分级A组与B组无统计学差异(P>0.05),C组与其余3组比较有统计学差异(P<0.05)。组织学观测:术后3、8周A、B、D组胶原纤维排列紊乱,C组胶原纤维排列整齐。[结论]TGFβ1抗体复合生物蛋白胶可以有效预防术后肌腱粘连,不影响肌腱的正常愈合进程。

关键词(KeyWords)： 肌腱损伤;肌腱粘连;TGF-β1抗体;生物蛋白胶;鸡

Abstract:

Keywords:

基金项目(Foundation): 山东省卫生厅计划基金资助项目(编号:2003CA1CFB1)

作者(Author): 窦永峰;房清敏;王志刚;孙兆忠;仲江波;

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参考文献(References)：

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