张星晨;郑欣;孙玛骥;李成宇;芮敏;冯硕;赵凤朝;郭开今;

• 1:徐州医科大学附属医院
• 2:江苏省江阴市人民医院

摘要(Abstract)：

[目的]通过血栓弹力图(thrombelastography,TEG)评估静脉应用不同剂量氨甲环酸(tranexamic acid,TXA)对全膝关节置换术女性患者血栓形成的影响。[方法]2015年9月~2017年5月在徐州医科大学附属医院行单侧初次全膝关节置换女性患者63例,年龄49~85岁,平均(66.92±7.98)岁。随机分为加强组33例和对照组30例。加强组患者分别于切皮前和术后3 h各静脉给予TXA 1 g,共计2 g;对照组仅在切皮前静脉给予TXA 1 g,共计1g。于术前、术后1 d、术后7 d行TEG、血常规、凝血4项、D-二聚体及双下肢动静脉彩超检测。统计围手术期失血量、输血量、输血率、血栓发生率。[结果]加强组与对照组TEG、D-二聚体、PT和APTT各时间点的差异均无统计学意义(P>0.05),加强组围手术期失血量、输血量低于对照组,但差异无统计学意义(P>0.05)。两组血栓发生率分别为18.18%和23.33%,差异无统计学意义(P>0.05)。[结论]TEG是监测关节置换患者围手术期血栓形成的有效指标。1 g与2 g TXA剂量差异不影响女性TKA患者凝血全过程、围手术期失血量、输血率及术后血栓发生率。

关键词(KeyWords)： 血栓弹力图;关节置换;氨甲环酸;血栓;失血

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(编号:81672184);; 江苏省卫生计生委面上项目(编号:H201528);; 江苏省级社会发展重点项目(编号:BE2015627);; 江苏省青年医学人才基金项目(编号:QNRC2016801)

作者(Author): 张星晨;郑欣;孙玛骥;李成宇;芮敏;冯硕;赵凤朝;郭开今;

Email:

DOI:

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