牛东生;白志刚;王维军;

• 1:宁夏回族自治区人民医院骨二科
• 2:宁夏医科大学

摘要(Abstract)：

[目的]探讨非创伤性股骨头坏死(nontraumatic osteonecrosis of femoral head,NONFH)股骨头局部碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)与骨形态发生蛋白-2(bone morphogenic proteins,BMP-2)表达的变化情况及其意义。[方法]收集经全髋关节置换术取下的NONFH的股骨头标本30例作为实验组,新鲜股骨颈骨折标本10例作为对照组。于坏死区、健存区取材,经固定、脱钙后,制成切片,光镜观察其病理变化,并运用原位杂交技术分别对其bFGF与BMP-2的表达情况进行检测。[结果]实验组组织结构紊乱,破碎,骨小梁稀疏、不完整,有大量的空骨陷窝,而对照组骨小梁相对较完整、排列整齐,骨小梁中的骨细胞清晰可见,偶见空骨陷窝。实验组中bFGF与BMP-2的阳性表达强度及面积均明显低于对照组,结果有统计学意义(P<0.05)。[结论]NON-FH股骨头局部bFGF与BMP-2表达的降低,极有可能是导致其自身修复能力不足的重要原因。增加股骨头局部bF-GF与BMP-2的表达可能有助于股骨头缺血坏死的修复。

关键词(KeyWords)： 非创伤性股骨头坏死;碱性成纤维细胞生长因子;骨形态发生蛋白-2;表达

Abstract:

Keywords:

基金项目(Foundation): 宁夏回族自治区自然科学基金项目(编号:NZ08136)

作者(Author): 牛东生;白志刚;王维军;

Email:

DOI:

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