程轩洁;余青州;国乐乐;康凯;李彤;高石军;

• 1:河北医科大学第三医院关节二科河北省骨科生物力学重点实验室

摘要(Abstract)：

[目的]探讨全膝关节置换患者局部应用氨甲环酸(tranexamic acid,TXA)对下肢深静脉血栓(deep venous thrombosis,DVT)发生率的影响。[方法]回顾分析2014年1月~2015年10月于本院接受全膝关节置换(total knee arthroplasty,TKA)的526例患者的基本信息及临床资料,其中未使用氨甲环酸的患者291例(非氨甲环酸组),局部应用氨甲环酸的患者235例(氨甲环酸组),按照血栓危险因素-体重指数,将两组患者分为正常体重、超重及肥胖三个亚层,在每个亚层中匹配年龄、性别、凝血功能等影响血栓形成的危险因素,分析比较三个亚层中氨甲环酸组和非氨甲环酸组下肢深静脉血栓发生率的差异。[结果]正常体重患者中,氨甲环酸组的DVT发生率为11.1%,非氨甲环酸组DVT发生率为10.4%,两组血栓发生率比较差异无统计学意义(χ~2=0.01,P>0.05);超重患者中,氨甲环酸组的DVT发生率为14.0%,非氨甲环酸组DVT发生率为13.0%,两组血栓发生率比较差异无统计学意义(χ~2=0.05,P>0.05);肥胖患者中,氨甲环酸组的DVT发生率为28.0%;非氨甲环酸组DVT发生率为16.3%,两组血栓发生率差异有统计学意义(χ~2=4.70,P<0.05),且差异主要来自两组肌间静脉血栓发生率的不同(19.6%vs7.4%,χ~2=7.48,P<0.05)。[结论]在国人正常体重及超重的低血栓风险患者中,膝关节置换术中局部运用氨甲环酸对下肢深静脉血栓发生无影响,肥胖患者应用氨甲环酸将增加下肢深静脉血栓,尤其是肌间静脉血栓发生的风险。

关键词(KeyWords)： 氨甲环酸;关节成形术;置换;血栓形成;体重指数

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 程轩洁;余青州;国乐乐;康凯;李彤;高石军;

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参考文献(References)：

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