个性化3D打印多孔钛合金加强块重建重度髋臼骨缺损的生物相容性和生物力学研究Biocompatibility and biomechanics of individualized 3D printed porous Ti6Al4V augment for acetabular bone defect in pig
付君;倪明;陈继营;邓涛;管海涛;贾承奇;徐驰;柴伟;郝立波;
摘要(Abstract):
[目的]评价巴马小型猪髋臼骨缺损模型个性化3D打印多孔钛合金加强块多孔内骨长入情况和生物力学性能。[方法]在巴马小型猪建立髋臼缺损模型,制备个性化3D打印多孔钛合金加强块置于缺损处。扫描电子显微镜测量多孔钛合金加强块多孔涂层内部结构参数(孔隙率、孔径和梁径),CT扫描三维重建测量个性化加强块置入术后的匹配率;力学试验机测量加强块的刚度、抗压强度和弹性模量以及加强块置入术后的生物力学;Micro-CT检查评价加强块多孔涂层内的骨长入和骨整合。[结果]钛合金加强块内部结构参数,总孔隙率为(55.48±0.61)%,孔径(319.23±25.05)μm,梁径(240.10±23.50)μm;力学性能参数:刚度为(21 464.60±1 091.69)N/mm,抗压强度为(231.10±11.77)MPa,弹性模量为(5.35±0.23)GPa。加强块置入术后的匹配度为:(91.40±2.83)%。Micro-CT扫描结果显示个性化3D打印多孔钛合金加强块的多孔涂层内有骨小梁长入;个性化3D打印多孔钛合金加强块置入术后即刻和12周最大抗剪切强度载荷值分别为(929.46±295.99)N和(1 521.93±98.38)N(P=0.030)。[结论]本研究中设计的个性化3D打印多孔钛合金加强块具有良好的骨组织生物相容性和生物力学性能。
关键词(KeyWords): 髋臼骨缺损;钛合金;生物力学;生物相容性
基金项目(Foundation): 国家高技术研究发展计划(863计划)项目[编号:2015AA033501]
作者(Author): 付君;倪明;陈继营;邓涛;管海涛;贾承奇;徐驰;柴伟;郝立波;
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