酚磺乙胺联合氨甲苯酸对初次单侧全膝关节置换术后出血量影响的临床研究Blood loss control using etamsylate and aminomethylbenzoic acid during primary unilateral total knee arthroplasty
李继超;尹东;黄宇;郑帮明;黄晓;
摘要(Abstract):
[目的]探讨酚磺乙胺联合氨甲苯酸对初次单侧全膝关节置换术后出血量的影响。[方法]根据随机对照原则设计,选取2009年3月~2013年3月拟行单侧全膝关节置换术的患者70例,男24例,女46例;年龄56~79岁,平均66.76岁,病因:骨性关节炎59例,类风湿性关节炎8例,创伤性关节炎3例,病程3~19年,随机分为试验组和对照组(n=35),试验组在松止血带时将酚磺乙胺0.5 g和氨甲苯酸0.3 g稀释于生理盐水20 ml中缓慢注射,对照组给予等量生理盐水静脉注射,比较试验组与对照组患者术中出血量、术后引流量、输血量、术后血红蛋白值和术后纤维蛋白原、凝血酶原时间、活化部分凝血活酶时间,观察患者是否出现下肢深静脉栓塞及肺栓塞的临床症状,必要时行下肢彩色多普勒超声检查。[结果]试验组和对照组术中出血量比较差异无统计学意义(P>0.05),试验组术后引流量、总出血量、输血数、输血率均少于对照组,差异有统计学意义(P<0.05);术后24 h血红蛋白水平,试验组高于对照组,差异有统计学意义(P<0.05);两组患者纤维蛋白原、凝血酶原时间和活化部分凝血活酶时间的比较差异均无统计学意义(P>0.05);术后至少随访3~6个月,均未发现下肢深静脉血栓形成及肺栓塞发生。[结论]在初次单侧全膝关节置换术中联合使用酚磺乙胺和氨甲苯酸,能减少患者术后出血量及输血量,且不增加静脉血栓事件的风险。
关键词(KeyWords): 酚磺乙胺;氨甲苯酸;膝关节置换;出血
基金项目(Foundation):
作者(Author): 李继超;尹东;黄宇;郑帮明;黄晓;
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DOI:
参考文献(References):
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