韩利伟;侯海燕;张杰;

• 1:南阳南石医院脊柱关节科

摘要(Abstract)：

[目的]分析老年髋部骨折围术期Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、碱性磷酸酶(ALP)、胰岛素样生长因子-1 (IGF-1)水平的测定及临床意义。[方法] 2018年2月～2019年6月,89例老年髋部骨折患者纳入本研究。其中,合并骨质疏松症52例,未合并骨质疏松症37例;男30例,女59例。检测患者术前,术后第1、7 d和14 dβ-CTX、ALP、IGF-1水平。[结果] 89例患者均顺利手术,围手术期无死亡者,无严重并发症发生。89例患者随时间推移,β-CTX含量显著上升(P<0.05),而ALP和IGF-1水平显著下降(P<0.05)。相应时间点,骨质疏松组β-CTX水平显著高于非骨质疏松组(P<0.05),而骨质疏松组的ALP和IGF-1水平均显著低于非骨质疏松组(P<0.05)。女性β-CTX水平均显著高于男性(P<0.05),而女性ALP和IGF-1水平均显著低于男性(P<0.05)。[结论]老年髋部骨折患者围术期β-CTX水平上升,ALP、IGF-1水平下降,且在骨质疏松和女性患者骨丢失更为明显,可能反映骨吸收大于骨形成。

关键词(KeyWords)： 老年;髋部骨折;Ⅰ型胶原羧基端肽β特殊序列(β-CTX);碱性磷酸酶(ALP);胰岛素样生长因子-1(IGF-1)

Abstract:

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作者(Author): 韩利伟;侯海燕;张杰;

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参考文献(References)：

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