郭洪刚;刘静;李峰坦;刘海峰;姚芳莲;姚康德;

• 1:天津医科大学总医院骨科
• 2:天津市中心妇产科医院
• 3:新加坡国立大学组织工程研究中心
• 4:天津大学材料学院

摘要(Abstract)：

[目的]分析数字化影像学技术辅助研制生物支架的可行性,评估构筑生物支架的方法。[方法]通过对宿主部位图像扫描,获取该区域解剖数据,对相邻层匹配轮廓间三维表面进行重构来确定支架形貌,以纳米级无机成分为单位,附于壳聚糖及聚己内酯等天然-有机成分,研制纳米复合支架。观察支架形貌、测定支架的孔隙率、亲水性及降解力学特性。[结果]图像三维重构可提高支架外部轮廓的精确度,减少单纯理化制备过程的参数误差,使支架空间三维布局更加合理,孔径200~350μm,孔隙率88.6%±0.43%的支架拥有稳定的降解速率及良好的亲水表面,可达到工程化骨支架的力学要求,能作为骨再生修复的载体框架。[结论]数字化影像学技术研制的支架具有稳定的理化性征,能解决与宿主部位相匹配的难题,具有潜在的研究空间。

关键词(KeyWords)： 图像;三维重建;纳米;支架

Abstract:

Keywords:

基金项目(Foundation): 天津市卫生局科技基金资助项目(编号:06KZ46)

作者(Author): 郭洪刚;刘静;李峰坦;刘海峰;姚芳莲;姚康德;

Email:

DOI:

参考文献(References)：

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