王林伟;刘明廷;任强;石辉;李健;徐闯;

• 1:滨州医学院附属医院骨关节外科

摘要(Abstract)：

随着生活质量的改善以及生活水平的提高,肌肉骨骼系统疾病的患者越来越多,其中骨关节炎(OA)、韧带损伤和软骨损伤最常见。由于软骨再生和愈合能力差,这就促使人们寻找其他治疗方法来提高其治愈能力,加上患者对快速恢复活动的期望,也要求医者来寻找一种更有效和更微创的治疗方案。因此,使用生物制剂来治疗肌肉骨骼疾病便成为了一种潜在的选择。尽管近几年来使用生物制剂来治疗肌肉骨骼疾病的病例越来越多,但是,这些生物制剂的治疗效果却并不相同。目前广泛支持使用的生物制剂富血小板血浆(platelet-rich plasma, PRP)其最佳制备方法和制备产品的治疗效果在文献中阐述的较少。本文主要从PRP的制备方法及治疗肌肉骨骼系统疾病两个方面来探讨一下其相关研究进展。

关键词(KeyWords)： 富血小板血浆;肌肉骨骼疾病;研究进展

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王林伟;刘明廷;任强;石辉;李健;徐闯;

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参考文献(References)：

• [1]Lana JF, Weglein A, Sampson SE, et al. How should we evaluate outcomes for use of biologics in the knee[J]. J Stem Cells Regen Med, 2016, 12(2):69-78.
• [2]Andia I, Maffulli N. How far have biological therapies come in regenerative sports medicine[J]. Expert Opin Biol Ther, 2018, 18:785-793.
• [3]Anitua E. Plasma rich in growth factors:preliminary results of use in the preparation of future sites for implants[J]. Int J Oral Maxillofac Implants, 1999, 14(4):529-535.
• [4]Landesberg R, Roy M, Glickman RS, et al. Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation[J]. J Oral Maxillofac Suig, 2000, 58:297-300.
• [5]Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects:A pilot study[J]. J Oral Maxillofac Surg, 2002, 60(10):1176-1181.
• [6]Petrungaro PS. Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery[J]. Compend Contin Educ Dent, 2001, 22(9):729.
• [7]Sonnleitner D, Huemer P, Sullivan DY. A simplified technique for producing platelet-rich plasma and platelet concentrate for intraoral bone grafting techniques:a technical note[J]. Int J Oral Maxillofac Implants, 2000, 15(6):879-882.
• [8]Weibrich G, Kleis WK, Hafner G. et al. Comparison of platelet,leukocyte, andgrowth factor levels in point-of-careplatelet-enriched plasma, prepared usinga modified Curasan kit, withpreparations received from a local bloodbank[J]. Clin Oral Implants Res, 2003, 14(3):357-362.
• [9]Weibrich G, Kleis WK, Buch R. et al. The Harvest Smart PRePTM system versusthe Friadent-Schutze platelet-rich plasma kit[J].Clin Oral Implants Res, 2003, 14(2):233-239.
• [10]Man D, Plosker H, Winland-Brown JE. The use of autologous platelet-rich plasma(platelet gel)and autologous platelet-poor plasma(fibrin glue)incosmetic surgery[J]. Plast Reconstr Surg,2001, 107(1):229-239.
• [11]Weibrich G, Kleis WK, Hitzler WE. et al. Comparison of the platelet concentrate collection system with the plasma-rich-in-growthfactors kit to produce platelet-rich plasma a technical report[J].Int J Oral Maxillofac Implants, 2005, 20(1):118-123.
• [12]Marlovits S, Mousavi M, G?bler C. et al. A new simplified technique for producing platelet-rich plasma a short technical note[J]. Eur Spine J, 2004, 13(Suppl 1):S102-106.
• [13]Andia I, Abate M. Platelet-rich plasma:combinational treatment modalities formusculoskeletal conditions[J]. Front Med, 2018, 12(2):1-14.
• [14]Zhu Y, Yuan M, Meng HY. et al. Basic science and clinical application of platelet-rich plasmafor cartilage defects and osteoarthritis:a review[J]. Osteoarthritis Cartilage, 2013, 21(11):1627-1637.
• [15]Chahla J, Cinque ME, Piuzzi NS. et al. A call for standardization in platelet-rich plasmapreparation protocols and composition reporting:a systematic review of the clinical orthopaedic literature[J]. J Bone Joint Surg Am, 2017, 99(20):1769-1779.
• [16]Campbell KA, Saltzman BM, Mascarenhas R. et al. Doesintra-articular platelet-rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis asystematicreview of overlapping meta-analyses[J].Arthroscopy, 2015, 31(11):2213-2221.
• [17]Ahmad HS, Farrag SE, Okasha AE. et al. Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis[J]. Int J Rheum Dis. 2018, 21(5):960-966.
• [18]Chang NJ, Erdenekhuyag Y, Chou PH, et al. Therapeutic effects of the addition of platelet-rich plasma to bioimplants and early rehabilitation exercise on articular cartilage repair[J]. Am J Sports Med, 2018, 46(9):2232-2241.
• [19]Laudy AB, Bakker EW, Rekers M. et al. Efficacy of platelet-rich plasma injectionsin osteoarthritis of the knee:a systematic reviewand meta-analysis[J]. Br J Sports Med, 2015, 49(10):657-672.
• [20]Bagwell MS, Wilk KE, Colberg RE. et al. The use of serial platelet rich plasma injections with early rehabilitation to expedite grade III medial collateral ligament injury in a professional athlete:a case report[J]. Int J Sports Phys Ther, 2018, 13(3):520-525.
• [21]Mahapatra P, Horriat S, Anand BS. Anterior cruciate ligament repair-past, present and future[J]. J Exp Orthop, 2018, 5(1):20.
• [22]Fleming BC, Proffen BL, Vavken P. et al. Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction[J]. Knee Surg Sports Traumatol Arthrosc, 2015, 23(4):1161-1170.
• [23]LaPrade CM, James EW, LaPrade RF. et al. Howshould we evaluate outcomes for use ofbiologics in the knee[J]. J Knee Surg,2015, 28(1):35-44.
• [24]Sample SJ, Racette MA, Hans EC. et al. Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs[J]. PLoS One, 2018, 13(6):e0197204.
• [25]Figueroa D, Figueroa F, Calvo R. et al. Platelet-rich plasma use in anterior cruciate ligament surgery:systematic review of the literature[J]. Arthroscopy, 2015, 31(5):981-988.
• [26]Kemmochi M, Sasaki S, Takahashi M. et al. The use of plateletrich fibrin with platelet-rich plasma support meniscal repair surgery[J]. J Orthop, 2018, 15(2):711-720.
• [27]Chahla J, Cinque ME, Piuzzi NS. et al. Acall for standardization in platelet-rich plasmapreparation protocols and composition reporting:a systematic review of the clinical orthopaedic literature[J]. J Bone Joint Surg Am, 2017, 99(20):1769-1779.
• [28]Dhillon M, Patel S, Bali K. Platelet-rich plasma intra-articular knee injectionsfor the treatment of degenerative cartilage lesionsand osteoarthritis[J]. Knee Surg Sports Traumatol Arthrosc,2011, 19(5):863-866.
• [29]Patel S, Dhillon MS, Aggarwal S. et al. Treatment with plateletrich plasma is moreeffective than placebo for knee osteoarthritis:a prospective, double-blind, randomizedtrial[J]. Am J Sports Med,2013, 41(2):356-364.