许晨辉;何阿祥;谢栋;陈洁;魏杰;杨立利;

• 1:第二军医大学附属长征医院脊柱三科
• 2:华东理工大学材料科学与工程学院

摘要(Abstract)：

[目的]通过动物体内置入实验评价介孔硅酸钙改性硫酸钙骨水泥(m CSC)在体内的降解性和成骨性能。[方法]将m CSC和对照样硫酸钙(CSC)骨水泥置入新西兰大白兔右侧股骨末端骨缺损,于术后4、8、12周取样,通过组织学和免疫组化分析骨水泥在体内的降解性和成骨性能。[结果]m CSC复合骨水泥置入兔股骨缺损部位12周后修复骨缺损,组织病理学和免疫组化分析表明:伴随着m CSC材料的降解,大量新生骨组织生成,成骨量显著高于CSC;且VEGF和Ⅰ型胶原染色阳性表达率明显高于CSC。[结论]m CSC具有优良的生物相容性、降解性和成骨性能,能促进新骨再生,是一种潜在的骨修复材料。

关键词(KeyWords)： 介孔硅酸钙;硫酸钙;复合骨水泥;降解性;成骨性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(编号:81572194);国家自然科学基金资助项目(编号:81371383);; 上海市曙光计划项目(编号:13SG38)

作者(Author): 许晨辉;何阿祥;谢栋;陈洁;魏杰;杨立利;

Email:

DOI:

参考文献(References)：

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