邱耿韬;史占军;赵亮;

• 1:南方医科大学南方医院关节与骨病外科

摘要(Abstract)：

<正>磷酸钙骨水泥(calcium phosphate cement,CPC)在1985年由Brown等人首次报道[1],CPC天然理化性质与人体骨骼成分相类似,生物兼容性好,无细胞毒性,能在低温固化和塑型,并且具有骨传导能力,因此,CPC一经面世便受到骨组织修复领域研究人员的

关键词(KeyWords)： 磷酸钙骨水泥;骨再生修复;羟基磷灰石;透磷灰石

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(青年项目)(编号:31100695);; 广州市“珠江科技新星”(2012027);; 广东省科技计划项目(编号:2012B010200024);; 广东省自然科学基金(编号:s20110003918)

作者(Author): 邱耿韬;史占军;赵亮;

Email:

DOI:

参考文献(References)：

• [1]Chow BA.A new calcium phosphate,watersetting cement[C].Ce-ments Research Progress,Westerville,Ohio,1987:352-379.
• [2]Mirtchi AA,Lemaitre J,Terao N.Calcium phosphate cements:studyof the beta-tricalcium phosphate-monocalcium phosphate system[J].Biomaterials,1989,7:475-480.
• [3]Liu C.Effects of the granularity of raw materials on the hydration andhardening process of calcium phosphate cement[J].Biomaterials,2003,23:4103-4113.
• [4]Aberg J.Premixed acidic calcium phosphate cement:characterizationof strength and microstructure[J].J Biomed Mater Res B Appl Bio-mater,2010,2:436-441.
• [5]Habraken WJ.Introduction of gelatin microspheres into an injectablecalcium phosphate cement[J].J Biomed Mater Res A,2008,3:643-655.
• [6]Barralet JE,Grover LM,Gbureck U.Ionic modification of calciumphosphate cement viscosity.Part II:hypodermic injection andstrength improvement of brushite cement[J].Biomaterials,2004,11:2197-2203.
• [7]Giocondi JL.Molecular mechanisms of crystallization impacting cal-cium phosphate cements[J].Philos Transact A Math Phys Eng Sci,2010,1917:1937-1961.
• [8]Pina S.In vitro performance assessment of new brushite-forming Zn-and ZnSr-substituted beta-TCP bone cements[J].J BiomedMater Res B Appl Biomater,2010,2:414-420.
• [9]Bohner M,Baroud G.Injectability of calcium phosphate pastes[J].Biomaterials,2005,13:1553-1563.
• [10]Livingston T,Ducheyne P,Garino J.In vivo evaluation of a bioactivescaffold for bone tissue engineering[J].J Biomed Mater Res,2002,1:1-13.
• [11]Huan Z,Chang J.Novel bioactive composite bone cements based onthe beta-tricalcium phosphate-monocalcium phosphate mono-hydrate composite cement system[J].Acta Biomater,2009,4:1253-1264.
• [12]Wu F,Su J,Wei J,et al.Injectable bioactive calcium-magnesiumphosphate cement for bone regeneration[J].Biomed Mater,2008,4:044105.
• [13]Vazquez D.Effects of addition of mannitol crystals on the porosityand dissolution rates of a calcium phosphate cement[J].J Res NatlInst Stand Technol,2010,4:225-232.
• [14]Silva TS.Use of calcium phosphate cement scaffolds for bone tissueengineering:in vitro study[J].Acta Cir Bras,2011,1:7-11.
• [15]吴飞雁,刘兴炎,陈克明,等.大孔径速降解磷酸钙骨水泥的制备[J].中国矫形外科杂志,2008,15:1181-1184.
• [16]Kuang GM.An effective approach by a chelate reaction in optimizingthe setting process of strontium-incorporated calcium phosphatebone cement[J].J Biomed Mater Res B Appl Biomater,2012,3:778-787.
• [17]Wu F.Self-setting bioactive calcium-magnesium phosphate ce-ment with high strength and degradability for bone regeneration[J].Acta Biomater,2008,6:1873-1884.
• [18]Zhao L.Fatigue and human umbilical cord stem cell seeding charac-teristics of calcium phosphate-chitosan-biodegradable fiber scaf-folds[J].Biomaterials,2010,5:840-847.
• [19]Gorst NJ.Effects of fibre reinforcement on the mechanical propertiesof brushite cement[J].Acta Biomater,2006,1:95-102.
• [20]Hu G.Study on injectable and degradable cement of calcium sul-phate and calcium phosphate for bone repair[J].J Mater Sci MaterMed,2010,2:627-634.
• [21]Habraken WJ.In vivo degradation of calcium phosphate cement in-corporated into biodegradable microspheres[J].Acta Biomater,2010,6:2200-2211.
• [22]van de Watering FC.Calcium phosphate/poly(D,L-lactic-co-glycolic acid)composite bone substitute materials:evaluation of tem-poral degradation and bone ingrowth in a rat critical-sized cranialdefect[J].Clin Oral Implants Res,2012,2:151-159.
• [23]厉孟,刘旭东,刘兴炎,等.多孔明胶微球-磷酸钙骨水泥的制备及其性能研究[J].中国矫形外科杂志,2009,7:526-529.
• [24]Flautre B.Influence of polymeric additives on the biological proper-ties of brushite cements:an experimental study in rabbit[J].J Bi-omed Mater Res A,2003,2:214-223.
• [25]Wong CT.In vivo cancellous bone remodeling on a strontium-con-taining hydroxyapatite(sr-HA)bioactive cement[J].J BiomedMater Res A,2004,3:513-521.
• [26]Li X.The optimum zinc content in set calcium phosphate cement forpromoting bone formation in vivo[J].Mater Sci Eng C Mater BiolAppl,2009,3:969-975.
• [27]Lee GS.Alginate combined calcium phosphate cements:mechanicalproperties and in vitro rat bone marrow stromal cell responses[J].JMater Sci Mater Med,2011,5:1257-1268.
• [28]Lee GS.Direct deposited porous scaffolds of calcium phosphate ce-ment with alginate for drug delivery and bone tissue engineering[J].Acta Biomater,2011,8:3178-3186.
• [29]Moreau JL,Xu HH.Mesenchymal stem cell proliferation and differ-entiation on an injectable calcium phosphate-chitosan compositescaffold[J].Biomaterials,2009,14:2675-2682.
• [30]Rochet N.Differentiation and activity of human preosteoclasts on chi-tosan enriched calcium phosphate cement[J].Biomaterials,2009,26:4260-4267.
• [31]Lian Q.Mechanical properties and in-vivo performance of calciumphosphate cement-chitosan fibre composite[J].Proc Inst MechEng H,2008,3:347-353.
• [32]Ruhe PQ.Porous poly(DL-lactic-co-glycolic acid)/calciumphosphate cement composite for reconstruction of bone defects[J].Tissue Eng,2006,4:789-800.
• [33]Weir MD,Xu HH.Osteoblastic induction on calcium phosphate ce-ment-chitosan constructs for bone tissue engineering[J].J BiomedMater Res A,2010,1:223-233.
• [34]Zhao L.Osteogenic media and rhBMP-2-induced differentiation ofumbilical cord mesenchymal stem cells encapsulated in alginate mi-crobeads and integrated in an injectable calcium phosphate-chitosanfibrous scaffold[J].Tissue Eng Part A,2011,7-8:969-979.
• [35]扈延龄,李红,李树娟,等.复合rhBMP_2壳聚糖微球可注射磷酸钙骨水泥制备及成骨性能研究[J].中国矫形外科杂志,2010,20:1723-1726.
• [36]Gu Y.Evaluation of an injectable silk fibroin enhanced calciumphosphate cement loaded with human recombinant bone morphogenet-ic protein-2 in ovine lumbar interbody fusion[J].J Biomed MaterRes A,2011,2:177-185.
• [37]Ma CB.Bone morphogenetic proteins-signaling plays a role in ten-don-to-bone healing:a study of rhBMP-2 and noggin[J].Am JSports Med,2007,4:597-604.
• [38]Zhao L,Weir MD,Xu HH.An injectable calcium phosphate-algi-nate hydrogel-umbilical cord mesenchymal stem cell paste for bonetissue engineering[J].Biomaterials,2010,25:6502-6510.
• [39]Zhao L,Weir MD,Xu HH.Human umbilical cord stem cell encap-sulation in calcium phosphate scaffolds for bone engineering[J].Biomaterials,2010,14:3848-3857.
• [40]Zhu C.LvBMP-2 gene-modified BMSCs combined with calciumphosphate cement scaffolds for the repair of calvarial defects in rats[J].J Mater Sci Mater Med,2011,8:1965-1973.