赵轶男;刘建;刘昌盛;白峰;孟国林;郝赋;

• 1:第四军医大学西京医院全军骨科研究所
• 2:华东理工大学材料科学与工程学院生物材料研究所

摘要(Abstract)：

[目的]探讨孔径大小对多孔磷酸钙骨水泥(CPC)修复骨缺损能力的影响。[方法]用盐析法制备三种不同孔径(200～300μm、300～450μm、450～600μm)但孔隙率相同(68.3±3.3)%的多孔CPC材料,将材料植入兔大段桡骨缺损模型,术后4、12周进行大体观察、X线检查、血清骨源性碱性磷酸酶(BALP)检测、组织学观察和生物力学检测。[结果]术后4、12周X线检查可见200～300μm孔径材料骨缺损区愈合相对较好;4周时BALP检测200～300μm组高于其他组,差异具有统计学意义(P<0.05),12周BALP检测三组差异无统计学意义;12周组织形态计量学分析显示200～300μm材料组新生骨面积百分比最多,差异有统计学意义(P<0.05);力学结果显示200～300μm组材料的最大压缩载荷和弹性模量均好于其他两组,差异具有统计学意义(P<0.05)。[结论]孔径的大小可以影响骨生物材料在体内的成骨能力,本研究中较小孔径材料成骨能力更好,且更易达到成骨性能和力学性能的统一。

关键词(KeyWords)： 孔径;骨缺损;磷酸钙骨水泥;孔隙结构

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划(编号:2008BAI16B02)

作者(Author): 赵轶男;刘建;刘昌盛;白峰;孟国林;郝赋;

Email:

DOI:

参考文献(References)：

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