细胞黏附分子在骨肉瘤中的表达及其临床意义Expression of CD44V6,β-catenin in osteosarcoma and its clinical significance
李成存;张栋;李敏;
摘要(Abstract)：
[目的]检测CD44V6、β-catenin在骨肉瘤组织中的表达,分析其表达与人骨肉瘤细胞浸润及转移能力的相关性。[方法]应用免疫组织化学方法检测35例骨肉瘤、15例骨软骨瘤、15例正常骨组织中CD44V6、β-catenin的表达。[结果]骨肉瘤组织中CD44V6、β-catenin的阳性表达显著高于骨软骨瘤及正常骨组织(P<0.01);两者的表达分别与骨肉瘤临床分期、肿瘤转移及2年内死亡有关(P<0.05),而与患者性别、年龄、肿瘤大小、病理分型、术前化疗无关(P>0.05);两者的阳性表达呈正相关(P<0.01)。[结论]CD44V6、β-catenin在骨肉瘤的阳性表达与骨肉瘤的发生、发展和转移密切相关,可能在骨肉瘤细胞侵袭、转移的过程中起协同作用;联合检测CD44V6、β-catenin可以作为骨肉瘤的诊断和预测转移的指标。
关键词(KeyWords)： CD44V6;β-catenin;骨肉瘤;浸润;转移
基金项目(Foundation):
作者(Author): 李成存;张栋;李敏;
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参考文献(References)：
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