生物支架材料在骨-肌腱结点中的应用进展
闫军伟;李爱国;陈鸿辉;
摘要(Abstract):
<正>随着社会的发展,交通创伤、运动损伤以及过度负重导致的关节周围各种急慢性损伤越来越多见。膝部韧带的损伤及网球肘、跳跃膝等疾病的发病率逐年增高。据统计,全球每年约有3 000万例的肌腱韧带损伤的病例[1],这严重影响了人们的生活,并加重了社会的负担。过去的治疗方法,主要为手术解剖重建修复,即通过自体或异体肌腱的移植来治疗和修复肌腱,但在治疗过程中必须面对这样一个问题,即骨-肌腱结点的愈合缓慢而困难,而且在愈合过程中往往不伴随其特征性结
关键词(KeyWords): 骨-肌腱结点;生物支架;组织工程
基金项目(Foundation): 国家自然科学基金面上项目(编号:30973067);; 广州市卫生局重点项目(编号:201102A212003)
作者(Author): 闫军伟;李爱国;陈鸿辉;
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DOI:
参考文献(References):
- [1]Maffulli N,Wong J,Almekinders LC.Types and epidemiology of tendi-nopathy[J].Clin Sports Med,2003,4:675-692.
- [2]李宗虎,曲彦隆,周继辉,等.肌腱组织工程研究新进展[J].中国矫形外科杂志,2007,18:1406.
- [3]Benjamin M,Kumai T,Milz S,et al.Skeletal attachment of tendons-ten-don enthuses[J].Comp Biochem Physiol A Mol Integr Physiol,2002,4:931-945.
- [4]Lu H,Qin L,Cheung W,et al.Low-intensity pulsed ultrasound acceler-ated bone-tendon junction healing through regulation of vascular endo-thelial growth factor expression and cartilage formation[J].UltrasoundMed Biol,2008,8:1248-1260.
- [5]Wang Y,Kim HJ,Vunjak-Novakovic G,et al.Stem cell-based tissueengineering with silk biomaterials[J].Biomaterials,2006,36:6064-6082.
- [6]Hubbell JA.Bioactive biomaterials[J].Curr Opin Biotechnol,1999,2:123-129.
- [7]Lin CY,Kikuchi N,Hollister SJ.A novel method for biomaterial scaf-fold internal architecture design to match bone elastic properties with-desired porosity[J].J Biomech,2004,37:623-636.
- [8]Takezawa T.A strategy for the development of tissue engineering scaf-folds that regulate cell behavior[J].Biomaterials,2003,24:2267-2275.
- [9]Iwata Y,Morihara T,Tachiiri H,et al.Behavior of host and graft cells inthe early remodelingprocess of rotator cuff defects in a transgenic animalmodel[J].Shoulder Elbow Surg,2008,1:101-107.
- [10]Hibino N,Hamada Y,Sairyo K,et al.Callus formation during healing ofthe repaired tendon-bone junction.A rat experimental model[J].JBone Joint Surg Br,2007,11:1539-1544.
- [11]Sundar S,Pendegrass CJ,Blunn GW.Tendon bone healing can be en-hanced by demineralized bone matrix:a functional and histological stud-y[J].J Biomed Mater Res B Appl Biomater,2009,1:115-122.
- [12]李爱国,陈鸿辉,江斌,等.骨膜促进骨-肌腱结点愈合的研究[J].中国矫形外科杂志,2011,1:50-53.
- [13]Wong MW,Qin L.Articular cartilage increases transition zone regenera-tion in bone-tendon junction healing[J].Clin Orthop,2009,4:1092-1100.
- [14]Kim HJ,Kang SW,Lim HC,et al.The role of transforming growth fac-tor-beta and bone morphogenetic protein with fibrin glue in healing ofbone-tendon junction injury[J].Connect Tissue Res,2007,6:309-315.
- [15]秦胜男,陈鸿辉.胶原在软骨组织工程中的应用[J].中国矫形外科杂志,2009,13:998-10000.
- [16]卢华定,蔡道章,秦骥,等.Ⅰ型胶原负载骨髓基质干细胞修复兔膝关节软骨缺损[J].Chin J Bone Joint Inj,6:453-4561.
- [17]Yates KE,Allemann F,Glowaeki J.Phenotypic analysis of bovine chon-drocytes cultured in 3D collagen sponges:effect of serum substi-tutes[J].Cell Tissue Bank,2005,1:45-54.
- [18]Ma CB,Kawamura S,Deng XH,et al.Bone morphogenetic proteins-sig-naling plays a role in tendon-to-bone healing:a study of rhBMP-2 andnoggin[J].Am J Sports Med,2007,4:597-604.
- [19]Heckmann L,Schlenker HJ,Fiedler J,et al.Human mesenchymal pro-genitor cell responses to a novel textured poly(L-lactide)scaffold forligament tissue engineering[J].J Biomed Mater Res B Appl Biomater,2007,1:82-90.
- [20]Lu HH,Cooper JA Jr,Manuel S,et al.Anterior cruciate ligament regen-eration using braided biodegradable scaffolds:in vitro optimization stud-ies[J].Biomaterials,2005,23:4805-4816.
- [21]Smith LL,Niziolek PJ,Haberstroh KM,et al.Decreased fibroblast andincreased osteoblast adhesionon nanostructured NaOH-etched PLGAscaffolds[J].Int J Nanomedicine,2007,3:383-388.
- [22]Arévalo-Silva CA,Eavey RD,Cao Y,et al.Internal support of tissue-en-gineered cartilage[J].Arch Otolaryngol Head Neck Surg,2000,12:1448-1452.
- [23]Sahoo S,Toh SL,Goh JC.PLGA nanofiber-coated silk microfibrousscaffold for connective tissue engineering[J].J Biomed Mater Res BAppl Biomater,2010,1:19-28.
- [24]Chen X,Qi YY,Wang LL,et al.Ligament regeneration using a knittedsilk scaffold combined with collagen matrix[J].Biomaterials,2008,27:3683-3692.