梁冬波;李林青;唐福宇;王俞波;李剑峰;田凯;杨威;陈华明;兰曦;

• 1:广西柳州市中医医院

摘要(Abstract)：

[目的]研究老年骨质疏松症患者脂肪细胞因子与骨密度的相关性。[方法]对180例受检者进行骨密度测定,根据骨密度测量T值分为骨质疏松组、骨量减少组各70例,骨量正常组即健康受检者40例,采用酶联免疫法检测受检者血清瘦素(leptin)、抵抗素(resistin)、脂联素(adiponectin)、内脂素(visfatin)、网膜素-1(omentin-1)和内源性配体(apelin)水平。[结果]三组血清Visfatin因子表达水平比较差异无统计学意义(P>0.05);而Leptin、Resistin、Adiponectin、Omentin-1、Apelin组间差异有统计学意义(P<0.01)。Pearson线性回归分析结果显示:腰椎骨密度与Leptin(B=0.145,P=0.044)呈线性正相关,与Resistin(B=-0.020,P=0.004)、Adiponectin(B=-0.031,P=0.008)、Omentin-1(B=-0.030,P=0.001)呈线性负相关。[结论]脂代谢异常可能与骨质疏松有关,提示脂肪细胞相关因子的异常表达对老年骨质疏松症的发病有一定的影响。

关键词(KeyWords)： 骨质疏松;脂肪细胞因子;骨密度;相关性

Abstract:

Keywords:

基金项目(Foundation): 广西自然科学青年基金项目(编号:2015jjBA40179)

作者(Author): 梁冬波;李林青;唐福宇;王俞波;李剑峰;田凯;杨威;陈华明;兰曦;

Email:

DOI:

参考文献(References)：

• [1]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中华骨质疏松和骨矿盐疾病杂志,2017,20(5):413-443.
• [2]Xie YM,Yuwen Y,Dong FH,et al.Clinical practice guideline of traditional medicine for primary osteoporosis[J].Chin J Integr Med,2011(1):1-10.
• [3]左旭阳,杨奕,李姝婷,等.绝经后女性骨密度与脂代谢的相关性研究[J].中国全科医学,2016,19(16):1903-1906.
• [4]中国老年学学会骨质疏松委员会.中国人骨质疏松症诊断标准专家共识(第3稿)[J].中国骨质疏松杂志,2014,20(9):1007-1010.
• [5]Garnero P.New developments in biological markers of bone metabolism in osteoporosis[J].Bone,2014,(66):46-55.
• [6]Thomas T,Gori F,Khosla S,et al.Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes[J].Endocrinology,1999,140:1630-1638.
• [7]Blain H,Vui llemin A,Guillemin F,et al.Serum leptin level is a predictor of bone mineral densi ty in postmenopausal women[J].JClin Endocrinol Metab,2002,87:1030-1035.
• [8]Biver E,Salliot C,Combescure C,et al.Influence of adipokines and ghrelin on bone mineral density and fracture risk:a systematic review and meta-analysis[J].J Clin Endocrinol Metab,2011,96(9):2703-2713.
• [9]Helena J,Anders O,Lerner Ulf H,et al.High serum adiponectin predicts incident fractures in elderly men:osteoporotic fractures in men(MrOS)Sweden[J].J Bone Miner Res,2012,27(6):1390-1396.
• [10]Biver E.Influence of adipokines and ghrelin on bone mineral density and fracture risk:a systematic review and meta-analysis[J].JClin Endocrinol MeTab,2011,96(9):2703-2713.
• [11]Abke S,Neumeier M,Weigert J,et al.Adiponectin-induced secretion of interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1,CCL2)and interleukin-8(IL-8,CXCL8)is impaired in monocytes from patients with type I diabetes[J].Cardiovasc Diabetol,2006,30(5):17.
• [12]Oh KW,Lee WY,Rhee EJ,et al.The relationship between serum resist in,leptin,adiponectin,ghrelin levels and bone mineral density in middle-aged men[J].Clin Endocrinol(Oxf),2005,63:131-138.
• [13]Zabetian Targhi F.Modulatory role of omentin-1 in inflammation:cytokines and dietary intake[J].J Am Coll Nutr,2016,35(8):670-678.
• [14]Tohidi M.Omentin-1,visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women[J].Bone,2012,51(5):876-881.
• [15]Guo LJ,Jiang TJ,Liao L,et al.Relationship between serum omentin-1 level and bone mineral density in girls with anorexia nervosa[J].J Endocrinol Invest,2013,36(3):190-194.
• [16]Rao SS,Hu Y,Xie PL,et al.Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines[J].Bone Res,2018,6:9.
• [17]Majid A.Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis:the crosstalk between bone and adipose tissue[J].Plos One,2011,6(9):e24240.
• [18]Wang L,Yuan JS,Zhang HX,et al.Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture[J].Chin J Traumatol,2011,14(1):7-13.
• [19]Wang L,Tang X,Zhang H,et al.Elevated leptin expression in rat model of traumatic spinal cord injury and femoral fracture[J].JSpinal Cord Med,2011,34(5):501-509.
• [20]Ducy P,Amling M,Takeda S,et al.Leptin inhibits bone formation through a hypothalamic relay:a central control of bone mass[J].Cell,2000,100(2):197-207.