王志鹏;张晓刚;李元贞;张宏伟;赵希云;曹盼举;蒋宜伟;

• 1:甘肃中医药大学附属医院骨科
• 2:甘肃中医药大学

摘要(Abstract)：

[目的]系统评价经皮椎体后凸成形术(PKP)与保守方法治疗骨质疏松性椎体压缩骨折(OVCF)的有效性和安全性。[方法]计算机检索CNKI、CBM、WanFang Data、VIP、PubMed、The Cochrane Library以及EMbase数据库,搜集关于PKP对比保守方法治疗OVCF的随机对照试验,检索时限均从建库至2017年7月。由两位评价员独立筛选文献、提取数据并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行荟萃分析。[结果]最终纳入9个RCT研究,共计1 156例患者,PVP治疗548例,保守治疗608例。短-中期随访PKP组在VAS评分、椎体后凸畸形、生活质量评分方面优于保守组,差异有统计学意义(P<0.05)。但长期随访两组VAS评分、椎体再骨折率、并发症发生率差异无统计学意义(P>0.05)。此外,PKP组在椎体高度、椎体高度丢失率和椎体后凸畸形角方面明显优于保守组,差异有统计学意义(P<0.05)。[结论]现有证据表明,PKP手术治疗OVCF短、中期疗效优于保留治疗,两种治疗方式在安全性方面无显著差异。受纳入研究质量和随访时间的限制,未来还需更多远期随访的大样本、高质量的RCT研究来进一步验证。

关键词(KeyWords)： 经皮椎体后凸成形术;保守治疗;骨质疏松;椎体压缩骨折;荟萃分析

Abstract:

Keywords:

基金项目(Foundation): 甘肃省中医药管理局支撑项目(编号:GZK-2017-17)

作者(Author): 王志鹏;张晓刚;李元贞;张宏伟;赵希云;曹盼举;蒋宜伟;

Email:

DOI:

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