发育性髋关节脱位早期髋臼软骨细胞凋亡的实验研究Experimental study on acetabular cartilage cell apoptosis of early developmental dislocation of the hip
王炳海;韦宜山;丁良甲;边鸿飞;崔兆鹏;王海瑞;
摘要(Abstract):
[目的]探讨发育性髋关节脱位(DDH)早期髋臼软骨是否发生了过度的细胞凋亡,随着时间的推移细胞凋亡发生的规律如何。[方法]选取新西兰大白兔40只,雌雄不限,月龄4周,体重(0.5±0.05)kg,采用兔后肢伸膝屈髋位管型石膏固定方法制作DDH模型。将实验动物左后肢管型石膏固定为实验侧,右后肢不做处理定为空白对照侧。[结果]DDH早期髋臼软骨细胞确实存在过度细胞凋亡,脱位时间越长凋亡现象越严重,且髋臼指数明显增大。[结论]实验证实了DDH早期髋臼软骨细胞过度的细胞凋亡可能参与了DDH髋臼软骨发育不良。
关键词(KeyWords): 髋脱位;软骨细胞;细胞凋亡
基金项目(Foundation):
作者(Author): 王炳海;韦宜山;丁良甲;边鸿飞;崔兆鹏;王海瑞;
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DOI:
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