丁晓明;徐宝山;杨强;

• 1:天津医科大学研究生院
• 2:天津市天津医院

摘要(Abstract)：

[目的]综述国内外有关丝素蛋白应用于椎间盘纤维环组织工程的研究进展,为下一步的实验研究提供理论依据。[方法]广泛查阅近年来国内外有关丝素蛋白的研究成果,尤其是应用于椎间盘纤维环组织工程的相关文献,归纳总结其发展现状和研究进展。[结果]目前丝素蛋白提纯工艺已臻成熟,并且在多个领域得到应用,比如纤维环、软骨、肌腱、韧带组织工程和药物缓释材料等方面。以丝素蛋白为材料制成的支架,结构稳定,力学强度高,还具有良好的生物相容性和可控的生物降解速率,并且能够通过简单的化学修饰来改进各方面的性能。[结论]丝素蛋白作为椎间盘纤维环组织工程支架的理想材料,表现出了良好的发展前景,值得进一步研究和推广。

关键词(KeyWords)： 椎间盘;纤维环;丝素蛋白;组织工程

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(编号:31000432,81272046);; 中国博士后科学基金资助项目(编号:2011M500530,2012T50235);; 天津市卫生局科技基金重点资助项目(编号:2013KR16)

作者(Author): 丁晓明;徐宝山;杨强;

Email:

DOI:

参考文献(References)：

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