蒋涛;任先军;

• 1:第三军医大学新桥医院骨科

摘要(Abstract)：

关键词(KeyWords)： 脊髓损伤;组织工程;脊髓支架

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(编号:30872600);; 重庆市自然科学基金重点项目(编号:CSTC2008BA5007)

作者(Author): 蒋涛;任先军;

Email:

DOI:

参考文献(References)：

• [1]Zhang N,Yan H,Wen X.Tissue-engineering approaches for axonal guidance[J].Brain Res Brain Res Rev,2005,1:48-64.
• [2]Takezuwa T.A strategy for the development of tissue engineering scaf-folds that regulate cell behavior[J].Biomaterials,2003,13:2267-2275.
• [3]Novikova LN,Kellerth JO,Novikov LN.Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury[J].Curr Opin Neurol,2003,6:711-715.
• [4]Madaghiele M,Sannino A,Yannas IV,et al.Collagen-based matrices with axially oriented pores[J].J Biomed Mater Res A,2008,3:757-767.
• [5]Ma W,Fitzgerald W,Liu QY,et al.CNS stem and progenitor cell dif-ferentiation into functional neuronal circuits in three-dimensional col-lagen gels[J].Exp Neurol,2004,2:276-288.
• [6]Hatami M,Mehrjardi NZ,Kiani S,et al.Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord[J].Cytotherapy,2009,5:618-630.
• [7]Ju YE,Janmey PA,McCormick ME,et al.Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels[J].Biomaterials,2007,12:2097-2108.
• [8]Johnson PJ,Tatara A,Shiu A,et al.Controlled release of neurotrophin-3and platelet derived growth factor from fibrin scaffolds containing neural progenitor cells enhances survival and differentiation into neu-rons in a subacute model of SCI[J].Cell Transplant,2009,9:198.
• [9]Suzuki Y,Kitaura M,Wu S,et al.Electrophysiological and horseradish peroxidase-tracing studies of nerve regeneration through alginate-filled gap in adult rat spinal cord[J].Neurosci Lett,2002,3:121-124.
• [10]Prang P,Muller R,Eljaouhari A,et al.The promotion of oriented ax-onal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels[J].Biomaterials,2006,19:3560-3569.
• [11]李晓光,杨朝阳,张皑峰,等.应用壳聚糖导管-生物活性载体系统修复大鼠脊髓损伤[J].中国康复理论与实践,2003,3:176-178.
• [12]程映华,梁晶,王晓冬,等.壳聚糖神经干细胞复合物修复大鼠完全性脊髓损伤的组织学观察[J].中华实验外科杂志,2004,1:26-27.
• [13]Novikov LN,Novikova LN,Mosahebi A,et al.A novel biodegradableimplant for neuronal rescue and regeneration after spinal cord injury[J].Biomaterials,2002,16:3369-3376.
• [14]Novikova LN,Pettersson J,Brohlin M,et al.Biodegradable poly-beta-hydroxybutyrate scaffold seeded with Schwann cells to promote spi-nal cord repair[J].Biomaterials,2008,9:1198-1206.
• [15]Krych AJ,Rooney GE,Chen B,et al.Relationship between scaffold channel diameter and number of regenerating axons in the transected rat spinal cord[J].Acta Biomater,2009,7:2551-2559.
• [16]Li XK,Cai SX,Liu B,et al.Characteristics of PLGA gelatin complex as potential artificial nerve scaffold[J].Colloids Surf Biointerfaces,2007,2:198-203.
• [17]Shi R,Borgens RB.Anatomical repair of nerve membranes in crushed mammalian spinal cord with polyethylene glycol[J].J Neurocytol,2000,9:633-643.
• [18]Luo J,Shi R.Polyethylene glycol inhibits apoptotic cell death following traumatic spinal cord injury[J].Brain Res,2007,1155:10-16.
• [19]Laverty PH,Leskovar A,Breur GJ,et al.A preliminary study of intra-venous surfactants in paraplegic dogs:polymer therapy in canine clini-cal SCI[J].J Neurotrauma,2004,12:1767-1777.
• [20]Kamalesh S,Tan P,Wang J,et al.Biocompatibility of electroactive pol-ymers in tissues[J].J Biomed Mat Res,2000,3:467-478.
• [21]Schmidt CE,Shastri VR,Vacanti JP,et al.Stimulation of neurite out-growth using an electrically conducting polymer[J].Proc Natl Acad Sci USA,1997,17:8948-8953.
• [22]郭树章,任先军,蒋涛,等.脱细胞脊髓天然支架的制备及形态学观察[J].中国矫形外科杂志,2007,3:226-228.
• [23]郭树章,任先军,蒋涛,等.脱细胞脊髓支架的成分分析[J].第三军医大学学报,2007,13:1246-1249.
• [24]郭树章,任先军,蒋涛,等.大鼠脱细胞异体脊髓支架的免疫原性研究[J].中国矫形外科杂志,2007,6:444-446.
• [25]Guo SZ,Ren XJ,Wu B,et al.Preparation of the acellular scaffold of the spinal cord and the study of biocompatibility[J].Spinal Cord,2010,7:576-581.
• [26]Tom VJ,Doller CM,Malouf AT,et al.Astrocyte-associated fibronec-tin is critical for axonal regeneration in adult white matter[J].J Neu-rosci,2004,42:9282-9290.
• [27]Gulati AK.Immunological fate of Schwann cell-populated acellular basal lamina nerve allografts[J].Transplantation,1995,11:1618-1622.
• [28]薛辉,陈东,张秀英,等.化学去细胞肌肉促进大鼠脊髓半横断后的轴突再生[J].西安交通大学学报,2009,2:154-158.
• [29]薛辉,陈东,张秀英,等.化学去细胞肌肉组织工程支架与大鼠脊髓的生物相容性[J].吉林大学学报,2009,5:801-806.