孙培锋;曲良;夏国峰;胡健;陈君;吴冰;

• 1:解放军第401医院骨一科

摘要(Abstract)：

[目的]探讨白藜芦醇对椎板切除术后硬膜外粘连的预防作用。[方法]60只Wistar大鼠行L_2椎板切除术,形成3 mm×3 mm硬膜裸露区,随机平均分为3组。A组:术后给予白藜芦醇药物溶液干预;B组:术后给予生理盐水干预;C组:单纯椎板切除术组。术后6周处死动物并取材,行羟脯氨酸(hydroxyproline hyp)含量分析;肉眼观察硬膜外粘连情况,并行Rydell分级;样品行石蜡包埋并切片后,行免疫组织化学、HE染色。[结果]术后6周A组较B组、C组粘连程度轻,Rydell分级具有统计学意义(P<0.05),B组、C组间差异无统计学意义(P>0.05);A、B、C三组硬膜外瘢痕组织中羟脯氨酸的含量分别为(27.95±4.88)μg/mg、(42.85±4.57)μg/mg、(43.95±5.73)μg/mg,A组较B组、C组少,差异有统计学意义(P<0.05),B组、C组间差异无统计学意义(P>0.05);单位成纤维细胞及波形蛋白计数,A组较B组和C组少,差异有统计学意义(P<0.05),B组、C组间差异无统计学意义(P>0.05)。[结论]白藜芦醇能够良好的预防大鼠椎板切除术后出现的硬膜外粘连,并可抗炎及抑制成纤维细胞增殖。

关键词(KeyWords)： 椎板切除术;硬膜外粘连;白藜芦醇;腰椎手术失败综合征

Abstract:

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作者(Author): 孙培锋;曲良;夏国峰;胡健;陈君;吴冰;

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参考文献(References)：

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