陶崑;沈灏;张先龙;王琦;邵俊杰;彭晓春;

• 1:上海交通大学附属第六人民医院骨科

摘要(Abstract)：

[目的]应用植骨气囊模型观察红霉素和阿伦磷酸钠防治人工关节松动的效果。[方法]应用8~10周大的BALB/c小鼠建立气囊模型,气囊成熟后在气囊内植入同基因小鼠颅骨,同时在气囊内注入超高分子聚乙烯颗粒。实验分4组:空白组气囊和腹腔均注射生理盐水(阴性对照);颗粒刺激组气囊注射聚乙烯颗粒,腹腔注射生理盐水(阳性对照);红霉素组气囊注射聚乙烯颗粒,腹腔注射红霉素;阿伦磷酸钠组气囊注射聚乙烯颗粒,腹腔注射阿伦磷酸钠。14d后处死,取囊壁和植入颅骨组织进行组织形态学和分子生物学检测。[结果]红霉素和阿伦磷酸钠组破骨细胞激活均受抑制,两者无显著差别。但红霉素组IL-1、TNF和VEGF含量明显下降,气囊炎性反应减轻,而阿伦磷酸钠无此抗炎作用。[结论]本试验证明红霉素和阿伦磷酸钠均有可能成为延缓和治疗人工关节松动的药物。

关键词(KeyWords)： 红霉素;阿伦磷酸钠;植骨气囊;动物模型;溶骨;人工关节松动

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陶崑;沈灏;张先龙;王琦;邵俊杰;彭晓春;

Email:

DOI:

参考文献(References)：

• [1]张超,汤亭亭,戴尅戎.人工关节无菌性松动药物治疗进展[J].中国矫形外科杂志,2007,6:15.
• [2]Ren W,Yang SY,Wooley PH.A novel murine model of orthopaedic wear-debris associated osteolysis[J].Scand J Rheumatol,2004,33:349-357.
• [3]Fornasier VL,Goodman SB,Protzner K,et al.The role of implant a-lignment on stability and particles on periprosthetic osteolysis-a rab-bit model of implant failure[J].J Biomed Mater Res B Appl Bio-mater,2004,15,70:179-186.
• [4]Cervin A.The anti-inflammatory effect of erythromycin and its deriv-atives,with special reference to nasal polyposis and chronic sinusitis[J].Acta Otolaryngol,2001,21:83-92.
• [5]Ren W,Wu B,Peng X,et al.Erythromycin inhibits wear debris-in-duced inflammatory osteolysis in a murine model[J].J Orthop Res,2006,24:280-290.
• [6]Desaki M,Okazaki H,Sunazuka T,et al.Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epitheli-al cells:possible role in the signaling pathway that regulates nuclear factor-{kappa}b activation[J].Antimicrob Agents Chemother,2004,48:1581-1585.
• [7]Shanbhag AS.Use of bisphosphonates to improve the durability of total joint replacements[J].J Am Acad Orthop Surg,2006,14:215-225.
• [8]Bhandari M,Bajammal S,Guyatt GH,et al.Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty.A meta analysis[J].J Bone Joint Surg Am,2005,87:293-301.