庄腾丰;王华军;郑小飞;罗斯敏;吴文锐;肖磊;查振刚;

• 1:暨南大学附属第一医院骨关节科

摘要(Abstract)：

[目的]系统评价糖尿病与膝关节置换术后并发症的相关性。[方法]计算机检索电子数据库Pubmed,EMbase,The Cochrane library(2017年第11期),CBM,中国知网(CNKI),万方(Wan Fang),搜集糖尿病对膝关节置换术后并发症发生风险相关性的观察性研究,检索时间均为自建库至2017年11月。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,运用Revman 5.3软件进行Meta分析。[结果]最终纳入16篇文献,共626 535例患者。Meta分析结果显示:糖尿病人群接受膝关节置换术后发生深部感染的风险是非糖尿病人群的1.66倍(OR=1.66,95%CI=1.46~1.89,P<0.001),糖尿病人群接受膝关节置换术后发生深静脉血栓(deep vein thrombosis,DVT)的风险是非糖尿病人群的1.48倍(OR=1.48,95%CI=1.22~1.80,P<0.001),糖尿病人群接受膝关节置换术后的膝关节功能评分(KSS)低于非糖尿病组,差异有统计学意义(SMD=-0.13,95%CI=-0.24~-0.01,P=0.04)。森林结构图显示本次研究结果较为稳健,漏斗图提示存在发表偏倚的可能性较小。[结论]糖尿病与膝关节置换术后并发症具有相关性,糖尿病可增加膝关节置换术后并发症的发病风险。

关键词(KeyWords)： 糖尿病;膝关节置换;术后并发症;Meta分析

Abstract:

Keywords:

基金项目(Foundation): 中国博士后科学基金资助项目(编号:2015M582480,2017T100660);; 广东省自然科学基金项目(编号:2016A030313100);; 国家自然科学基金项目(编号:81601219)

作者(Author): 庄腾丰;王华军;郑小飞;罗斯敏;吴文锐;肖磊;查振刚;

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