李晗;陈百成;邵德成;董江涛;

• 1:河北医科大学第三医院骨科

摘要(Abstract)：

有大量证据显示,血管病理学在大多数关节疾病特别是在关节炎中发挥着重要作用。其主要发病机制包括静脉血栓导致长骨末端软骨下骨的小血管间歇性血流供应不足,由此造成软骨下骨血流量减少,组织间液也相应减少,软骨下骨缺血使关节软骨处的营养和气体交换受到限制,这是引起软骨退行性变的一个主要诱发因素。其次,软骨下骨缺血引起局部骨细胞凋亡,促使骨破骨性吸收,进而导致骨质对外层软骨的支撑作用减弱。深刻理解诱发骨关节炎的早期病因对于制定有效治疗的措施阻止关节炎的发病进程具有重要意义。

关键词(KeyWords)： 关节炎;血管病理;软骨下骨;骨细胞;凋亡

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李晗;陈百成;邵德成;董江涛;

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参考文献(References)：

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