人工假体周围骨溶解的基因治疗研究进展
程涛;戴闽;
摘要(Abstract)：
关键词(KeyWords)：
基金项目(Foundation): 江西省科技厅重大攻关项目资助(No.050211)
作者(Author): 程涛;戴闽;
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DOI:
参考文献(References)：
- (1)Haynes DR,C rotti TN,Zreiqat H.Regu lation of osteoclast activity inperi-implant tissues[J].B iomaterials,2004,25(20):4877-4885.
- (2)C Ioh isy JC,Frazier E,H irayama T,et al.RANKL is an essential cy-toldne m ed iator of polym ethylm ethacrylate particle induced osteoclasto-genesis[J].J O rthop Res,2003,21:202-212.
- (3)Baumann B,Rader CP,Seufert J,et al,E ffects of polyethylene andTiAIV wear particles on expression of RANK,RANKL and OPG mR-NA[J].Acta O rthop Scand,2004,75(3):295-302.
- (4)Mandelin J,L i TF,Hukkanen M,et al.Interface tissue fibrob lasts fromloose total h ip replacem ent prosthesis produce receptor activator of nu-clear factor-kappaB ligand,osteoprotegerin,and cathepsin K[J].JRheumatol,2005,32(4):713-720.
- (5)Sabokba A,Itonaga I,Sun SG,et al.Arthroplasty m embrane-derived fi-brob lasts d irectly induce osteoclast formation and osteolysis in asepticloosen ing[J].J O rthop Res,2005,23(3):511-519.
- (6)A.Sabokar,O.Kudo,N.A.Athanasou.Two d istinct cellu lar m echa-n ism s of osteoclast formation and bone resorption in periprosthetic oste-olysis[J].J O rthop Res,2003,21(1):73-80.
- (7)Pap G,et al.D evelopm ent and characteristics of a synoviai-like inter-face m embrane around cem ented tib ial hem i arthroplasties in a novelratmodel of aseptic prosthesis loosen ing[J].Arthritis Rheum,2001,44:956-963.
- (8)D eMan FH,TigchelaarW,Marti RK,et al.E ffects ofm echan ical com-pression of a fibrous tissue interface on bone w ith orw ithout h igh-den-sity polyethylene particles in a rabb it model of prosthetic loosen ing[J].J Bone Joint Surg Am,2005,87(7):1522-1533.
- (9)Skurla CP,P luhar GE,Frankel D J,et al.Assessing the dog as a modelfor human total h ip replacem ent.Analysis of 38 can ine cem ented femo-ral components retrieved at post-mortem[J].J Bone Joint Surg B r,2005,87(1):120-127.
- (10)E I-W arrak AO,O lm stead M,Schneider R,et al.An experim ental an i-malmodel of aseptic loosen ing of h ip prostheses in sheep to study earlyb iochem ical changes at the interface m embrane[J].BMC Muscu loske-let D isord,2004,3:5~7.
- (11)E I-W arrak AO,O im stead M,ApeitD,et al.An an imalmodel for inter-face tissue formation in cem ented h ip replacem ents[J].Vet Surg,2004,33(5):495-504.
- (12)WRen,SY Yang,PH W ooley.A novel murine model of orthopaed icwear-debris associated osteolysiso[J].Scand J Rheumatol,2004,33:349-357.
- (13)Sud S,et al.E ffects of cytok ine gene therapy on particu late induced in-flammation in the murine air pooch[J].Inflammation,2001,25:361-372.
- (14)Schwarz EM,et al.Quantitative small-an imal surrogate to evaluate dragefficacy in preventing wear debris-induced osteolysis[J].J O rthopRes,2000,18:549-555.
- (15)Schwarz EM,et al.Tumor necrosis factor-alpha/nuclear transcriptionfactor-kappaB signaling in periprosthetic osteolysis[J].J O rthop Res,2000,18:472-480.
- (16)Ch ilds LM,et al.In vivo RANK signaling b lockade using the receptoractivator ofNF-kappa B:Fc effectively prevents and am eliorates weardebris-induced osteolysis via osteoclast depletion w ithout inh ib iting os-teogenesis[J].J Bone M iner Res,2002,17:192-199.
- (17)Ch ilds LM,Goater J J,O Keefe R J,et al.E fficacy of etanercept forwear debris-induced osteolysis[J].J Bone M iner Res,2001,16:338-347.
- (18)Ch ilds LM,Goater JJ,O Keefe R J,et al.E ffect of antitumor necrosisfactor-alpha gene therapy on wear debris induced osteolysis[J].JBone Joint Surg Am,2001,83:1789-1797.
- (19)Carmody EE,et al.V iral interleuk in.10 gene inh ib ition of inflamma-tion,osteoclastogenesis,and bone resorption in response to titan iumparticles[J].Arthritis Rheum,2002,46:1298-1308.2000,97:1566-1571.
- (20)UIrich-V intherM,et al.Recomb inant adeno-associated virus m ed iatedosteoprotegerin gene therapy inh ib its wear debris induced osteolysis[J].J Bone Joint Surg Am,2002,84:1405-1412.
- (21)Yang SY,et al.Adeno-associated virus-m ed iated osteoprotegerin genetransfer protects against particu late polyethylene-induced osteolysis ina murine model[J].Arthritis Rheum,2002,46:2514-2523.
- (22)Sud S,et al.E ffects of cytok ine gene therapy on particu late induced in-flammation in the murine air pouch[J].Inflammation,2001,25:361-372.
- (23)Yang SY,et al.IL-10 and IL-1Ra gene transfer using retroviral vectorsam eliorates an experim ental inflammatory reaction to orthopaed ic weardebris[J].lnflamm Res,2002,51:342-350.
- (24)Yang SY,W u B,Mayton L,et al.Protective effects of IL-1Ra or vIL-10gene ransfer on a murine model ofwear debris-induced ostcolysis[J].Gene Ther,2004,(5):483-491.
- (25)Goater JJ,et al.E fficacy of ex vivo OPG gene therapy in preventingwear debris induced osteolysis[J].J O rthop Res,2002,20:169-173.
- (26)Yang SY,Sam Nasser,Markel DC,et al.Human periprosthetic tissueimplanted in severe comb ined immunodeficient m ice respond to genetransfer of a cytok ine inh ib itor[J].J Bone Joint Surg Am,2005,87:1088-1097.
- (27)de Poorter JJ,Tolboom TC,Rabelink M J,et al.Towards gene therapyin prosthesis loosen ing:efficient k illing of interface cells by gene-d i-rected enzym e prodrag therapy w ith n itroreduetase and the prodrugCB1954[J].J Gene M ed,2005,7(11):1421-1428.