徐鸿尧;赵建宁;包倪荣;

• 1:第二军医大学南京临床医学院
• 2:南京军区南京总医院骨科

摘要(Abstract)：

[目的]探讨肩袖损伤修复材料的研究现状和进展。[方法]在Pub Med、Sino Med上查阅国内外有关肩袖损伤修复材料使用的文献,进行汇总分类。[结果]目前应用在肩袖损伤的修复材料主要有细胞外基质材料、不可降解的合成材料以及可以降解的合成材料,此外在材料修复的同时还可以添加不同的生长因子和种子细胞从而促进修复过程。[结论]肩袖损伤后在多种因素的影响下,传统修复方法失败率较高。未来随着组织工程学和材料学的发展,新材料的运用可能会取得更加确切的效果。

关键词(KeyWords)： 肩袖损伤;组织工程;生物材料

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 徐鸿尧;赵建宁;包倪荣;

Email:

DOI:

参考文献(References)：

• [1]Brown BN,Valentin JE,Stewart-Akers AM,et al.Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component[J].Biomaterials,2009,30:1482-1491.
• [2]Dines DM,Moynihan DP,Dines JS,et al.Irreparable rotator cuff tears:what to do and when to do it;the surgeon's dilemma[J].Instr Course Lect,2007,56:13-22.
• [3]Burkhart SS,Diaz-Pagan JL,Wirth MA,et al.Cyclic loading of anchor-based rotator cuff repairs:confirmation of the tension overload phenomenon and comparison of suture anchor fixation transosseous fixation[J].Arthroscopy,1997,13:720-724.
• [4]Adams JE,Zobitz ME,Reach JS Jr,et al.Rotator cuff repair using an acellular dermal matrix graft:an in vivo study in a canine model[J].Arthroscopy,2006,22:700-709.
• [5]Encalada-Diaz I,Cole BJ,Macgillivray JD,et al.Rotator cuff repair augmentation using a novel polycarbonate polyurethane patch:preliminary results at 12 months'follow-up[J].J Shoulder Elbow Surg,2011,5:788-794.
• [6]MacG illivray JD,Fealy S,Terry MA,et al.Biomechanical evaluation of a rotator cuff defect model augmented with a bioresorbable scaffold in goats[J].J Shoulder Elbow Surg,2006,15:639-644.
• [7]Kathleen AD,Stephen F,Badylak SP,et al.Extracellular matrix scaffold devices for rotator cuff repair[J].J Shoulder Elbow Surg,2010,19:467-476.
• [8]Zheng MH,Chen J,Kirilak Y,et al.Porcine small intestine submucosa(SIS)is not an acellular collagenous matrix and contains porcine DNA:possible implications in human implantation[J].J Biomed Mater Res,2005,73:61-67.
• [9]Valentin JE,Badylak JS,McC abe GP,et al.Extracellular matrix bioscaffolds for orthopaedic applications a comparative histologic study[J].J Bone Joint Surg Am,2006,88:2673-2686.
• [10]Bond JL,Dopirak RM,Higgins J,et al.Arthroscopic replacement of massive,irreparable rotator cuff tears using a graft Jacket allograft:technique and preliminary results[J].Arthroscopy,2008,24:403-409.
• [11]Nicholson GP,Breur GJ,Van Sickle D,et al.Evaluation of a crosslinked acellular porcine dermal patch for rotator cuff repair augmentation in an ovine model[J].J Shoulder Elbow Surg,2007,16:184-190.
• [12]Sandor M,Xu H,Connor J,et al.Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair[J].Tissue Eng Part A,2008,14:2021-2031.
• [13]Xu H,Wan H,Sandor M,et al.Host response to human acellular dermal matrix transplantation in a primate model of abdominal wall repair[J].Tissue Eng Part A,2009,14:2009-2019.
• [14]Raeder RH,Badylak SF,Sheehan C,et al.Natural anti-galactose alpha1,3 galactose antibodies delay,but do not prevent the acceptance of extracellular matrix xenografts[J].Transpl Immunol,2002,10:15-24.
• [15]Daly KA,Stewart-Akers AM,Hara H,et al.Effect of the alphaG al epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model[J].Tissue Eng Part A,2009,15:3877-3888.
• [16]Zalavras CG,Gardocki R,Huang E,et al.Reconstruction of large rotator cuff tendon defects with porcine small intestinal submucosa in an animal model[J].J Shoulder Elbow Surg,2006,15:224-231.
• [17]Perry SA,Gupta RR,Van Kleunen J,et al.Use of small intestine submucosa in a rat model of acute and chronic rotator cuff tear[J].J.Shoulder Elbow Surg,2007,16:179-183.
• [18]Sclamberg SG,Tibone JE,Itamura JM,et al.Sixmonth magnetic resonance imaging follow-up of large and massive rotator cuff repairs reinforced with porcine small intestinal submucosa[J].J Shoulder Elbow Surg,2004,13:538-541.
• [19]Iannotti JP,Codsi MJ,Kwon YW,et al.Porcine small intestine submucosa augmentation of surgical repair of chronic two-tendon rotator cuff tears-A randomized,controlled trial[J].J Bone Joint Surg Am,2006,88:1238-1244.
• [20]Nada AM,Debnath UK,Robinson DA,et al.Treatment of massive rotator-cuff tears with a polyester ligament(Dacron)augmentation clinical outcome[J].J Bone Joint Surg Am,2010,92:1397-1402.
• [21]King JB,Bulstrode C.Polylacetate-coated carbon-fiber in extraarticular reconstruction of the unstable knee[J].Clin Orthop,1985,196:139-142.
• [22]Audenaert E,Van Nuffel J,Schepens A,et al.Reconstruction of massive rotator cuff lesions with a synthetic interposition graft:a prospective study of 41 patients[J].Knee Surg Sports Traumatol Arthrosc,2006,14:360-364.
• [23]Moffat KL,Kwei AS,Spalazzi JP,et al.Novel nanofiber-based scaffold for rotator cuff repair and augmentation[J].Tissue Eng,2009,15:115-126.
• [24]Smith MJ,Smith DC,White KL,et al.Immune response testing of electrospun polymers:an important consideration in the evaluation of biomaterials[J].J Eng Fibers Fabr,2007,2:41-47.
• [25]Taylor ED,Nair LS,Nukavarapu SP,et al.Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease[J].J Bone Joint Surg Am,2010,92:170-179.
• [26]Hakimi O,Murphy R,Stachewicz U,et al.An electrospun polydioxanone patch for the localisation of biological therapies during tendon repair[J].Eur Cell Mater,2012,24:344-357.
• [27]Rnjak-Kovacina J,Weiss AS.Increasing the pore size of electrospun scaffolds[J].Tissue Eng Part B Rev,2011,5:365-372.
• [28]Liu CF,Aschbacher-Smith L,Barthelery NJ,et al.What we should know before using tissue engineering techniques to repair injured tendons:a developmental biology perspective[J].Tissue Eng Part BRev,2011,17:165-176.
• [29]Banes AJ,Tsuzaki M,Hu P,et al.PDGF-BB,IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro[J].J Biomech,1995,28:1505-1513.
• [30]Chang J,Thunder R,Most D,et al.Studies in flexor tendon wound healing:neutralizing antibody to TGF-beta1 increases postoperative range of motion[J].Plast Reconstr Surg,2000,105:148-155.
• [31]Lee JY,Zhou Z,Taub PJ,et al.BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo[J].Plos One,2011,6:17531.
• [32]Shine K,Horibe S,Hamada M,et al.Allograft anterior cruciate ligament reconstruction[J].Tech Knee Surg,2002,2:78-85.
• [33]Yoshikawa T,Tohyam AH,Katsura T,et al.Efects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after an terior cruelate ligament reconstruction in sheep[J].Am J Sports Med,2006,34:1918-1925.
• [34]Hoppe S,Alini M,Benneker LM,et al.Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors[J].J Shoulder Elbow Surg,2013,22:340-349.
• [35]Wang QW,Chen ZL.The committed differentiation of bone illarrow mesenchymal stem cells into tenocytes[J].Med J Chin PLA,2005,30:47-50.