陈大福;田伟;行勇刚;周一新;曹晶晶;王猛;

• 1:北京市创伤骨科研究所
• 2:北京积水潭医院
• 3:北京积水潭医院
• 4:北京积水潭医院

摘要(Abstract)：

[目的]研究胶原支架(CS)对磷酸钙骨水泥(CPC)的力学及其在体内成骨的影响。[方法]试验分CPC/CS及CPC两组,三点弯曲试验测试材料的强度和弹性模量;组织学观察材料植入兔股骨22及54周的成骨状况。[结果]CPC/CS比CPC的弯曲强度、韧性强度分别提高了64.2%、3 933.3%,弹性模量降低了45.7%;组织学显示22周CPC/CS内的胶原支架已完全被新骨替代,CPC只在边缘有少量成骨及材料降解而内部无成骨;54周CPC/CS已大部分降解孔化,孔内充满大量新骨及髓样组织,而CPC边缘区的成骨及材料降解虽比22周时明显,但其内部仍未见成骨。[结论]胶原支架既可改善CPC的力学性能,又能促进新骨长入CPC/CS复合材料内部,因此,CPC/胶原支架是较好的骨缺损修复材料。

关键词(KeyWords)： 磷酸钙骨水泥;胶原支架;骨形成

Abstract:

Keywords:

基金项目(Foundation): 北京自然科学基金资助项目(2982007)

作者(Author): 陈大福;田伟;行勇刚;周一新;曹晶晶;王猛;

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DOI:

参考文献(References)：

• [1]Friedman CD,Costantino PD,Takagi S,et al.BoneSource(tm)hydroxyapatite cem ent:a novel b iomaterial for cran iofacial skeletaltissue engineering and reconstruction[J].J B iom edMaterRes(ApplB iomater),1998,43:428-32.
• [2]Hock in H.K.Xu,Frederick C.E ichm iller,Anthony A.G iuseppetti.Reinforcem ent of a self-setting calcium phosphate cem entw ith d iffer-ent fibers[J].Journal of B iom ed ical Materials Research,2000,52(1):107-114.
• [3]Von Gonten AS,Kelly JR,Antonucci JM.Load-bearing behavior ofa simu lated cran iofacial structure fabricated from a hydroxyapatite ce-m ent and b ioresorbab le fiber-m esh[J].J Mater Sci Mater M ed,2000,11(2):95-100.
• [4]Hock in H.K.Xu,Janet B.Qu inn,Shozo Takagi,et al.Strong andmacroporous calcium phosphate cem ent:E ffects of porosity and fiberreinforcem ent on m echan ical properties[J].J B iom ed Mater Res,2001,57(3):457-66.
• [5]Kou ich iro Ohura,Marc Bohner,P ierreHardou in.Resorption of,andbone formation from,newβ-tricalcium phosphate-monocalcium phos-phate cem ents:An in vivo study[J].J B iom ed Mater Res,1996,30:193-200.
• [6]Hock in H.K.Xu,Janet B.Qu inn,Shozo Takagi,et al.E ichm iller.Strong and macroporous calcium phosphate cem ent:E ffects of porosi-ty and fiber reinforcem ent on m echan ical properties[J].J B iom edMater Res,2001,57:457-466.
• [7]Hock in H.K.Xu,Janet B.Qu inn,Shozo Takagi,et al.Synergisticreinforcem ent of in situ harden ing calcium phosphate composite scaf-fold for bone tissue engineering[J].B iomaterials,2004,25:1029-1037.
• [8]Lu is A lberto dos Santos,Rau l Garcia Carrodeguas,Anselmo O rtegaBosch i,.F iber-enriched doub le-setting calcium phosphate bone ce-m ent[J].J B iom ed Mater Res,2003,65:244-250.
• [9]P.D.Costantino,C.D.Friedman,K.Jones,et al.S isson.Ex-perim ental hydroxyapatite cem ent cran ioplasty[J].P last.Reconstr.Surg,1992,90:174-185.
• [10]B.R.Constantz,I.C.Ison,M.T.Fu lm er,et al.Skeletal repairby in situ formation of the m ineral phase of bone[J].Science 1995,267:1796-1799.