庄颖;陈建明;李长青;黄博;周跃;

• 1:解放军第59医院脊柱外科
• 2:第三军医大学新桥医院骨科

摘要(Abstract)：

[目的]设计构建一种新型组织工程椎间盘的复合支架材料,为组织工程椎间盘的实验研究奠定基础。[方法]应用冷冻干燥、化学交联等组织工程技术构建一种包含有纤维环和髓核两部分、全新的组织工程化椎间盘支架材料,并对其理化性能进行初步分析。[结果]所制备的组织工程支架材料为三维立体多孔结构,外周纤维环部分平均孔径为(251±147)μm;中间髓核部分平均孔径为(102±29)μm;支架材料孔隙率平均为84.3%。吸水力平均为73.3%,体外生物降解率平均为(37.1±3.5)%。生物力学测试结果表明,组织工程椎间盘支架材料具有与天然椎间盘相似的弹性以及抗压强度。[结论]作者所制备的组织工程椎间盘支架材料符合理想支架材料的结构要求,可对其生物学性能进行进一步实验研究。

关键词(KeyWords)： 椎间盘;组织工程;支架材料

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(项目编号:81071496、81071498)

作者(Author): 庄颖;陈建明;李长青;黄博;周跃;

Email:

DOI:

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