董翠翠;贺付成;

• 1:郑州大学第一附属医院
• 2:郑州大学

摘要(Abstract)：

[目的]采用系统评价及Meta分析的方法对局部应用和静脉注射氨甲环酸两种方式减少全膝关节置换术术后出血的临床效果进行评价。[方法]检索Cochrane Library、Medline、Embase、Pubmed英文数据库以及CBM、VIP、万方数据库、CNKI,检索内容为局部应用和静脉注射氨甲环酸的临床对照试验,使用Revman 5.30进行Meta分析。[结果]共纳入11篇文献,纳入患者1 948例,其中局部应用氨甲环酸754例,静脉注射氨甲环酸1 194例。局部应用与静脉注射氨甲环酸在术后失血量、术后输血率及血栓事件的发生方面差异均无统计学意义(P>0.05)。[结论]局部应用与静脉注射氨甲环酸在减少TKA术后出血的有效性和安全性并无差异,两种用药方式均可以减少TKA术后出血而不增加其血栓形成的风险。

关键词(KeyWords)： 氨甲环酸;静脉注射;局部应用;全膝关节置换术;荟萃分析

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 董翠翠;贺付成;

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参考文献(References)：

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