郑章;贾长青;梁峰;付勤;于云祥;

• 1:中国医科大学附属盛京医院脊柱关节外科

摘要(Abstract)：

[目的]系统评价多节段颈椎间盘置换术与颈椎前路减压椎间融合术(anterior cervical discectomy and fusion,ACDF)临床疗效的比较。[方法]检索Pubmed、Medline、EBSC0、Springer、Ovid、CNKI、Cochrane Library、外文医学期刊全文数据库(foreign journals integrations system)等数据库。收集1995～2010年发表的关于椎间盘置换与椎间融合临床疗效的随机对照试验(RCT),按Cochrane系统评价的方法评价纳入研究的质量和提取资料,并采用RevMan软件进行统计分析。术后疗效评价包括颈部功能残障指数(neck disability index,NDI),视觉模拟评分法(visual analogscale,VAS)及相应节段运动范围(range of motion,ROM)等常见指标。[结果]共8篇文献符合纳入标准,包括1734例患者;术后2年和4年NDI合并权重均差(weighted mean difference,WMD)分别为-7.82,(95%CI,-8.73～-6.91),(P<0.05);-5.92(95%CI,-9.89～-1.94),(P<0.05);术后1年和2年相应颈椎节段运动范围(ROM)汇总权重均差值分别为4.93(95%CI,2.08～6.71),(P<0.05);7.26(95%CI,6.82～7.69),(P<0.05)。术后2年的颈部和手臂疼痛VAS汇总权重均差值分别为-7.56(95%CI,-14.20～-0.92),(P<0.05);-5.26(95%CI,-10.01～-0.51),(P<0.05)。[结论]人工颈椎间盘置换术在术后2、4年内NDI均优于ACDF;1、2年内保留颈椎节段活动方面优于ACDF;2年内颈部及手部疼痛的缓解程度均优于ACDF。

关键词(KeyWords)： 颈椎人工间盘;颈前路减压椎间融合术;Meta分析

Abstract:

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作者(Author): 郑章;贾长青;梁峰;付勤;于云祥;

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参考文献(References)：

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