血清细胞因子在老年骨质疏松患者中的变化及临床意义
尹晓红;张西波;
摘要(Abstract)：
[目的]探讨老年骨质疏松患者瘦素(leptin)、肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)、胰岛素样生长因子1(IGF-1)水平的变化及其临床意义。[方法]选择2010~2014年驻地干休所老年患者80例,根据骨质疏松诊断标准分为骨质疏松组(osteoporosis group,35例)和骨量减少组(osteopenia group,45例),并选择同期老年体检患者30例为对照组。检测外周血血清Leptin、TNF-α、IL-2、IGF-1水平,并测定骨密度。[结果]骨质疏松组及骨量减少组血清IL-2和IGF-1水平均明显低于对照组(P<0.05),血清Leptin和TNF-α水平明显高于对照组(P<0.05);骨质疏松组与骨量减少组骨密度均明显低于对照组(P<0.05),同时骨质疏松组骨密度也明显低于骨量减少组(P<0.05);血清中IL-2和IGF-1水平与骨密度值均呈正相关(r=0.35,0.39,P<0.05),而Leptin、TNF-α与骨密度值呈负相关(r=-0.35,P<0.05)。[结论]Leptin、TNF-α、IL-2及IGF-1对辅助诊断和治疗老年骨质疏松症有一定的临床意义。
关键词(KeyWords)： 骨质疏松;瘦素;胰岛素样生长因子-1;骨密度;白细胞介素2
基金项目(Foundation):
作者(Author): 尹晓红;张西波;
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参考文献(References)：
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