钱光;余月明;董有海;洪洋;王明海;

• 1:复旦大学附属上海市第五人民医院骨科

摘要(Abstract)：

[目的]探讨磷酸钙复合BMP-2对骨质疏松状态下椎弓根螺钉稳定性的影响,评价其临床应用价值。[方法]雌性新西兰大白兔卵巢切除去势法制备骨质疏松模型,测量骨密度。将兔随机分为增强组和常规组,增强组采用磷酸钙复合BMP-2注入增强后置入椎弓钉,而常规组采用常规技术置入椎弓钉。置钉后4、8和12周分别进行骨组织形态计量检查和生物力学检测。[结果]与术前比较,卵巢切除后6个月的BMD显著下降(P<0.05),提示骨质疏松模型建立成功。置入L3椎弓螺钉术后4、8和12周,增强组和常规组骨形态计量指标比较,类骨质表面、骨-螺钉接触、骨内生和骨矿物沉积速率,均随时间延长显著增加,相同时间点增强组各项指标优于常规组,差异有统计学意义(P<0.05)。生物力学测试表明,置钉后4、8和12周,随着固定时间延长,两组的最大拔出力和最大破坏功耗均显著增加,相同时间点,增强组的最大拔出力和最大破坏功耗均显著大于常规组,差异有统计学意义(P<0.05)。[结论]磷酸钙复合BMP-2可以增强椎弓根螺钉在骨质疏松椎体中的稳定性,具有一定的临床应用价值。

关键词(KeyWords)： 骨质疏松症;椎弓根螺钉;磷酸钙;骨形态发生蛋白

Abstract:

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基金项目(Foundation): 上海市卫生和计划生育委员会科研课题面上项目(编号:201540312)

作者(Author): 钱光;余月明;董有海;洪洋;王明海;

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参考文献(References)：

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