胡凯;言湛军;成茂华;

• 1:苏州大学附属第二医院骨科

摘要(Abstract)：

腰痛是临床常见病和多发病,而腰椎间盘退变(intervertebral disc degeneration,IVDD)是引发腰痛的重要原因之一。椎间盘发生退变时,最主要的病理改变是细胞外基质降解加速和细胞凋亡数目增加,导致椎间盘正常结构破坏。目前临床上对于IVDD的治疗效果仍不甚满意,而组织工程修复技术的兴起,尤其基因技术领域的开启为IVDD的治疗带来了新的曙光。MicroRNAs是一类内源性非编码小RNA,其常规作用方式是通过与靶基因的3'UTR结合抑制靶基因的翻译过程,且其多靶点的作用方式,方便了microRNAs的临床应用。MicroRNAs与IVDD的关系已有相关报道,但研究局限,尚需从多方面进行深入探索。

关键词(KeyWords)： 椎间盘退变(IVDD);microRNA(miRNA);基因治疗

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 胡凯;言湛军;成茂华;

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参考文献(References)：

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