王健;谷文光;董志伟;

• 1:哈尔滨医科大学附属第一医院

摘要(Abstract)：

肿瘤微环境的细胞类型主要包括成纤维细胞,内皮细胞及浸润性免疫细胞,这些细胞都与肿瘤细胞相联系。它们可以通过改变microRNA的表达促进肿瘤的演进。microRNA参与肿瘤微环境诸多因素的调控,而微环境变化对肿瘤的发展起着重要的作用。研究microRNA在肿瘤及肿瘤微环境中的复杂作用有助于理解肿瘤的发展过程及为肿瘤疾病的诊断和预后提供新的思路。

关键词(KeyWords)： microRNA;癌细胞;肿瘤微环境

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王健;谷文光;董志伟;

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参考文献(References)：

• [1]Hanahan D,Coussens LM.Accessories to the crime:functions of cells recruited to the tumor microenvironment[J].Cancer Cell,2012,21(3):309-322.
• [2]Junttila MR,de Sauvage FJ.Influence of tumour micro-environment heterogeneity on therapeutic response[J].Nature,2013,501(7467):346-354.
• [3]Noy R,Pollard JW.Tumor-associated macrophages:from mechanisms to therapy[J].Immunity,2014,41(1):49-61.
• [4]Di Leva G,Garofalo M,Croce CM.MicroRNAs in cancer[J].Ann Rev Pathol,2014,9(2):287-314.
• [5]Lujambio A,Lowe SW.The microcosmos of cancer[J].Nature,2012,482(7385):347-355.
• [6]Zhu K,Pan Q,Zhang X,et al.MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression[J].Carcinogenesis,2013,34(9):2071-2079.
• [7]Sasaki K,Kohanbash G,Hoji A,et al.miR-17-92 expression in differentiated T cells-implications for cancer immunotherapy[J].J Transl Med,2010,8(1):17.
• [8]Roybal JD,Zang Y,Ahn YH,et al.miR-200 inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1[J].Mol Cancer Res,2011,9(1):25-35.
• [9]Verghese ET,Drury R,Green CA,et al.MiR-26b is down-regulated in carcinoma-associated fi broblasts from ER-positive breast cancers leading to enhanced cell migration and invasion[J].J Pathol,2013,231(3):388-399.
• [10]Mitra AK,Zillhardt M,Hua Y,et al.MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer[J].Cancer Discov,2012,2(12):1100-1108.
• [11]Muramatsu F,Kidoya H,Naito H,et al.microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin[J].Oncogene,2013,32(4):414-421.
• [12]Kong W,He L,Richards EJ,et al.Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer[J].Oncogene,2014,33(6):679-689.
• [13]Png KJ,Halberg N,Yoshida M,et al.A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells[J].Nature,2012,481(7380):190-194.
• [14]Nilsson S,Moller C,Jirstrom K,et al.Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration[J].PLo S One,2012,7(4):e36051.
• [15]Fang JH,Zhou HC,Zeng C,et al.MicroRNA-29b suppresses tumor angiogenesis,invasion,and metastasis by regulating matrix metalloproteinase 2 expression[J].Hepatology,2011,54(5):1729-1740.
• [16]Cha ST,Chen PS,Johansson G,et al.MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis[J].Cancer Res,2010,70(7):2675-2685.
• [17]Sasaki K,Kohanbash G,Hoji A,et al.miR-17-92 expression in differentiated T cells-implications for cancer immunotherapy[J].J Transl Med,2010,8(4):58-66.
• [18]Dudda JC,Salaun B,Ji Y,et al.MicroRNA-155 is required for effector CD8+T cell responses to virus infection and cancer[J].Immunity,2013,38(4):742-753.
• [19]Huffaker TB,Hu R,Runtsch MC,et al.Epistasis between microRNAs155 and 146a during T cell-mediated antitumor immunity[J].Cell Rep,2012,2(6):1697-1709.
• [20]Chen L,Ma H,Hu H,et al.Special role of Foxp3 for the specifically altered microRNAs in regulatory T cells of HCC patients[J].BMC Cancer,2014,14(1):489.