孙祥燚;张雷;赵建宁;周利武;

• 1:南京大学医学院附属金陵医院(解放军南京总医院)骨科

摘要(Abstract)：

[目的]探讨全膝关节置换术(TKA)后假体周围感染的临床诊断与治疗策略。[方法]回顾性分析2013年9月~2017年9月在本院收住的28例单侧TKA术后假体周围感染的病例,其中急性感染(Ⅱ型)4例,急性血源性感染(Ⅲ型)5例,慢性感染(Ⅳ型)19例;结合TKA术后假体周围感染的治疗标准及患者的期望和要求,其中11例行膝关节清创术,13例行Ⅱ期翻修术,3例行膝关节融合术,1例行抗结核治疗。评估患者术前与术后实验室检查指标(WBC、CRP和ESR)以及关节液培养作为诊断及治疗标准;并且评估膝关节的活动度(ROM)、VAS评分以及HSS评分。[结果]10例膝关节清创术、12例Ⅱ期翻修术以及3例膝关节融合术的患者感染均得到控制,1例急性血源性感染患者经单纯抗结核治疗后好转;另外2例最终选择截肢术。患者术前CRP和ESR均明显升高,关节穿刺液培养细菌检出率为39%;术后引流液培养均阴性,CRP和ESR值均明显下降。所有患者膝关节活动度明显改善、疼痛感明显减轻,末次随访膝关节HSS评分(82.91±7.49)分。[结论]CRP与ESR以及关节液穿刺培养可作为TKA术后感染的诊断及康复标准;全膝关节置换术后感染的治疗方案需结合假体周围感染的Sagawa分型和患者的期望而定。

关键词(KeyWords)： 全膝关节置换术;假体周围感染;诊断;临床治疗

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年科学基金项目(编号:81702170);; 江苏省自然科学基金青年科学基金项目(编号:BK20170624);; 中国博士后特别资助项目(编号:2017T100826)

作者(Author): 孙祥燚;张雷;赵建宁;周利武;

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DOI:

参考文献(References)：

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